| 异基因外周血干细胞移植移植物动力学观察(1例报告及文献复习) |
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| 引用本文： | 孟凡义,孙竞,刘晓力,冯茹,宋兰林,杨艺,牛京娜,周淑芸. 异基因外周血干细胞移植移植物动力学观察(1例报告及文献复习)[J]. 白血病．淋巴瘤, 2002, 11(4): 199-201. DOI: 10.3760/cma.j.issn.1009-9921.2002.04.002 |
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| 作者姓名： | 孟凡义 孙竞 刘晓力 冯茹 宋兰林 杨艺 牛京娜 周淑芸 |
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| 作者单位： | 第一军医大学南方医院，广东 广州 501515 |
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| 基金项目： | 军队科技攻关项目;012030; |
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| 摘 要： | 目的：观察移植物动力学变化，指导供者淋巴细胞输注(DLI)。方法：1例高龄慢粒白血病慢性期患者，在骨髓非清除性异基因外周血干细胞移植后，用细胞培养结合FISH法动态监测髓细胞和T淋巴细胞的嵌合状态，适时调整CsA剂量和进行DLI治疗。结果：+10天～+25天时大多数髓系、淋巴细胞完全性嵌合，但骨髓细胞嵌合的程度明显低于淋巴细胞。结论：嵌合体下降时减少CsA剂量和(或)应用DLI能够提高供受者造血细胞的嵌合率，消除残留白血病细胞，防止白血病复发。
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| 关 键 词： | 异基因干细胞 移植物 动力学 |
| 文章编号： | 1009-9921(2002)04-0199-03 |
| 修稿时间： | 2002-03-04 |
Analysis of Engraftment Kinetics After Allogeneic Peripheral Blood Stem Cell Transplantation-One Case Report with Peper Review |
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| MENG Fan-yi,SUN Jing,LOU Xiao-li,et al.. Analysis of Engraftment Kinetics After Allogeneic Peripheral Blood Stem Cell Transplantation-One Case Report with Peper Review[J]. Journal of Leukemia & Lymphoma, 2002, 11(4): 199-201. DOI: 10.3760/cma.j.issn.1009-9921.2002.04.002 |
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| Authors: | MENG Fan-yi SUN Jing LOU Xiao-li et al. |
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| Affiliation: | MENG Fan-yi,SUN Jing,LOU Xiao-li,et al.Nanfang Hospital,The first military medical university of PLA |
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| Abstract: | Objective:To study engraftment kinetic for directing donor lymphocyte infusion (DLI).Methods:Chimersim kinetic from T lymphocyte and myelocyte during allogenc peripheral blood stem cell transplantation in one patient with CML was analysied by FISH and cells cultur.The dosege of CsA and DLI was conditioned.Results:The most of myelocytic and T lymphocytic was complete chimersim on 20 to 25 days postransplantation.But the chimersim rate from myelocyte was significantly lower than T lymphocyte.The dosage decreased CsA and (or) DLI can improved chimersim rate for myeocyte and remove residue leukemic cells.Conclusion:To examing engraftment kinetic can direct DLI. |
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| Keywords: | Engraftment Kinetic Donor lymphocyte infusion |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
