| 麻黄碱旋光异构化新工艺研究 |
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| 引用本文： | 陈德军,王吉德,刘罡,邱晓连.麻黄碱旋光异构化新工艺研究[J].应用化工,2006,35(6):450-452. |
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| 作者姓名： | 陈德军 王吉德 刘罡 邱晓连 |
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| 作者单位： | 1. 新疆大学化学化工学院,新疆,乌鲁木齐,830046
2. 新疆和硕麻黄素制品有限责任公司,新疆,和硕,841200 |
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| 摘 要： | 介绍了将盐酸L-麻黄碱直接经过乙酰异构化、酸化水解工艺过程异构化为盐酸D-伪麻黄碱的新工艺,其工艺的优化条件是盐酸L-麻黄碱与乙酸酐的配比(摩尔比)为1∶3.5,酰化异构化温度100℃,酰化异构化时间7 h。酸化水解步骤所加入的浓盐酸(36.5%)与原料的配比(摩尔比)1.5∶1,酸化水解温度90℃,酸化水解时间8 h,产品盐酸D-伪麻黄碱收率大于98%。
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| 关 键 词： | 盐酸L-麻黄碱 盐酸D-伪麻黄碱麻黄素 异构化 酸化水解 |
| 文章编号： | 1671-3206(2006)06-0450-03 |
| 收稿时间： | 2006-03-03 |
| 修稿时间： | 2006年3月3日 |
Study on the new process for isomerization technology of ephedrine |
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| CHEN De-jun,WANG Ji-de,LIU Gang,QIU Xiao-lian.Study on the new process for isomerization technology of ephedrine[J].Applied chemical industry,2006,35(6):450-452. |
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| Authors: | CHEN De-jun WANG Ji-de LIU Gang QIU Xiao-lian |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering of Xinjiang University, Urmuqi 830046, China ; 2. Xinjiang Heshuo Ephedrine Product Co. , Ltd, Heshuo 841200, China |
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| Abstract: | D-pseudoephedrine hydrochloride was made from L-ephedrine hydrochloride through the isomerization,acidation,hydrolytic action,the optimum conditions are as follows:the mole ratio of L-ephedrine hydrochloride to acetic anhydride is 1∶3.5,the isomerization temperature is 100℃ and time is 7 h.In the acidation hydrolyzed reaction,the ratio of raw materials to hydrochloric is 1∶1.5,the acidation hydrolyzed temperature is 90℃ and time is 8 h.The product yield of D-pseudoephedrine hydrochloride is over 98%. |
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| Keywords: | L-ephedrine hydrochloride D-pseudoephedrine hydrochloride isomerization acidation hydrolyzed |
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