奈替米星与头孢他啶联合应用的抗生素后效应

［摘要］目的 探讨奈替米星与头孢他啶联合应用的抗生素后效应（PAE）.方法 采用微量稀释法测定MIC,采用棋盘设计、菌落计数法测定其PAE. 结果 奈替米星与头孢他啶对金黄色葡萄球菌、大肠埃希菌PAE较长,对铜绿假单胞菌PAE较小,单用与合用后PAE均呈浓度依赖性,两药合用后对金黄色葡萄球菌、大肠埃希菌PAE表现出明显的协同作用,对铜绿假单胞菌主要表现出相加作用. 结论 奈替米星联合头孢他啶使用可延长PAE,优于两药单独使用.

Post Antibiotic Effect of Netilmicin Combined with Ceftazidime

Objective To study the post antibiotic effect(PAE) of netilmicin combined with ceftazidime. Methods Staphylococcus aureus,Escherichia coti and Pseudomonas aeruginosa were used as target microorganisms.The minimal inhibitory concentration(MIC) of the drugs was determined with the microdilution method while the PAE was measured with the tessellaled design and colony counting method. Results Netilmicin combined with ceftazidine was shown to have stronger PAE on Staphylococcus aureus and Escherichia coli than that on Pseudomonas aeruginosa and the PAE of either drug used alone or both drugs used together was concentration dependent.Combined application of the 2 drugs was shown to exert a striking synergetic PAE on Staphylococcus aureus and Escherichia coli but only an additive effect on Pseudomonas aeruginosa. Conclusion Netilmicin combined with ceftazidime was shown to enhance the PAE on the bacteria used.Combined use of both drug is superior to the use of either drug alone.