Survivin在胃癌前病变与胃癌中的表达及其与Hp感染的相关性

目的 探讨Survivin在胃癌前病变与胃癌中的表达，并了解其表达与Hp感染的相关性。方法 Survivin检测采用免疫组化染色；Hp检测采用快速尿素酶试验与Giemsa染色。结果 30例胃癌前病变中有10例Survivin呈阳性（33．3％），30例胃癌有22例Survivin呈阳性（73．3％），两者比较差异有显著性（P〈0．05）。Hp在两种组织中差异无显著性（P〉O．5）。38例Hp阳性中有25例Survivin表达阳性（65．8％），13例阴性；22例Hp阴性中只有7例阳性（31．9％），15例呈阴性反应；两者相关比较差异有显著性（P〈0．05）。结论 survivin表达在胃癌前病变与胃癌中均有表达，随着病变加重，表达逐渐增加；Survivin表达与Hp感染相关。

Expression of survivin in GPL and gastric cancer and its correlation with helicobactor pylori infection

[Objective] To observe expression of survivin in gastric precancerous lesions(PGL)and gastric cancer,and its correlation with helicobactor pylori(Hp)infection.[Method] Sixty cases with pathologically confirmed GPL and gastric cancer were studied.The expression of survivin was determined by immunohistochemistry.Helicobactor pylori infection was determined by rapid urease test and giemasa staining.[Results] The positive expression rate of survivin in gastric cancer(73.3%)was significantly higher than that of PGL(33.3%),demonstrated the obvious difference(P <0.05).The rates of Hp infection in GPL and gastric cancer were 70%,58.6%,respectively,no statistical difference(P >0.5)found.The positive expression rate of survivin in Hp postive infection(25/38,65.8%)was higher than that of in Hp negative infection(7/20,31.9%).There were significant differences(P <0.05)between them.[Conclusion] Survivin is expressed in GPL and gastric cancer and expression of survivin is increasing with aggravation of pathological changes.There is obvious correlationship between expression of survivin and Hp infection.