新型冠状病毒肺炎中医证候学的系统评价和Meta分析

目的:通过系统评价新型冠状病毒肺炎(Coronavirus Disease 2019,COVID-19)中医证候学特征,为COVID-19中医辨证及治疗方案的制定及优化提供参考。方法:检索相关数据库和权威网站网站,并筛查参考文献,纳入COVID-19患者中医证候学得临床研究,研究类型不限。采用JBI评价工具和STATA 13分析软件进行质量评价和单组变量的Meta分析。结果:最终纳入10项研究。COVID-19确诊患者中医证候50个,发生率前10的主要症状为发热、纳差、乏力、咳嗽、口干、咳痰、纳呆、腹泻、肌肉酸痛、食欲减退。舌质分类4种:中淡红舌、红舌、暗红舌和绛红舌的发生率分别为33.4%,39.1%,23.3%和3.9%。舌苔表现15种,以腻苔(65.3%)、白苔(58.8%)为主。脉象分类8个,以沉脉(44.4%),、滑脉(40.1%)和数脉(21.3%为主)。结论:本研究首次采用循证医学方法进行COVID-19中医证候学研究,为全面考虑中医证候、降低漏诊、初步辨证提供当前可参考的综合证据。

Traditional Chinese Medicine Syndromes of the Novel Coronavious Pneumonica:A Systemic Review and Meta-analysis

Objective:To provide reference for the formulation and optimization of Novel Coronavious Pneumonica(NCP)syndrome differentiation and treatment schdule,through systematic review of TCM Syndromes of the NCP.Methods:Relevant databases and authoritative websites were retrieved and references were screened.Clinical studies of TCM syndromes in NCP patients were included without limiting the research type.The quality of included trial was evaluated by using JBI.Single variable Meta-analysis was conducted by Stata 13 software.Results:Ten studies were included.The analysis showed that there were 50 TCM syndromes diagnosed in NCP patients.The top 10 main symptoms were fever,poor appetite,fatigue,cough,dry mouth,expectoration,anorexia,diarrhea,muscle soreness,and loss of appetite.There were 4 types of tongue body:the incidence of pink tongue,red tongue,dark red tongue and Crimson tongue were 33.4%,39.1%,23.3%and 3.9%.There were 15 kinds of tongue coatings,which were mainly greasy coating(65.3%)and white coating(58.8%).There were 8 pulse patterns,which were mainly deep pulse(44.4%),slippery pulse(40.1%),and rapid pulse(21.3%).Conclusion:Evidence-based research for TCM syndromes of NCP were adopted in this study,which provided evidence for comprehensive consideration of TCM syndromes,reduction of missed diagnosis,and preliminary syndrome differentiation.