| 双氯芬酸钠滴眼液中苯扎氯铵的测定 |
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| 引用本文： | 李玮玲. 双氯芬酸钠滴眼液中苯扎氯铵的测定[J]. 中南药学, 2013, 0(3): 230-232 |
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| 作者姓名： | 李玮玲 |
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| 作者单位： | 广州市药品检验所,广州510160 |
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| 摘 要： | 目的采用HPLC双氯芬酸钠滴眼液中苯扎氯铵的含量。方法乙腈-5 mmol.L-1醋酸铵溶液（含1%三乙胺,用冰醋酸调节pH值至5.0±0.5）（65∶35）为流动相,CNW色谱柱（150 mm×4.6 mm,5μm）,检测波长为214 nm。结果苯扎氯铵的测定在12.50～125.00μg.mL-1与峰面积线性关系良好,苯扎氯铵的平均回收率为99.0%,RSD为1.3%。结论方法简单、灵敏度高,可用于双氯芬酸钠滴眼液中苯扎氯铵的测定。
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| 关 键 词： | 双氯芬酸钠滴眼液 苯扎氯铵 高效液相色谱法 |
Determination of benzalkonium chloride in diclofenac sodium eye drops |
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| LI Wei-ling. Determination of benzalkonium chloride in diclofenac sodium eye drops[J]. Central South Pharmacy, 2013, 0(3): 230-232 |
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| Authors: | LI Wei-ling |
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| Affiliation: | LI Wei-ling(Guangzhou Institute for Drug Control,Guangzhou 510160) |
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| Abstract: | Objective To develop a method to determine benzalkonium chloride in diclofenac sodium eye drops.Methods Separation was performed on a CNW column（150 mm×4.6 mm,5 μm）.The mobile phase consisted of acetonitrile： 5 mmol.L-1 ammonium acetate-1% triethylamine（adjusting pH to 5.0±0.5 by acetic acid） = 65 ∶ 35（v/v）.The UV detection was 214 nm.Results Benzalkonium chloride had a good linearity at 12.50-125.00 μg.mL-1,the average recovery of benzalkonium chloride was 99.0% and the RSD was 1.3%.Conclusion The method is simple,rapid and sensitive,and it could be applied to determine benzalkonium chloride in diclofenac sodium eye drops. |
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| Keywords: | diclofenac sodium eye drop benzalkonium chloride HPLC |
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