| 促血管生成素及其受体的异常表达与胃癌血管生成的关系 |
| |
| 引用本文： | 张真真,张声,林建银.促血管生成素及其受体的异常表达与胃癌血管生成的关系[J].中德临床肿瘤学杂志,2006,5(6):391-395. |
| |
| 作者姓名： | 张真真 张声 林建银 |
| |
| 作者单位： | [1]Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China [2]Department of Molecular Biology, Fujian Medical University, Fuzhou 350005, China [3]Department of Pathology, Fujian Medical University, Fuzhou 350005, China |
| |
| 摘 要： | Objective： To explore angiopoietins （Ang-1, Ang-2）/Tie-2 expression and angiogenesis in stomach carcinomas. Methods： RT-PCR and immunohistochemistry were used to detect angiopoietins/Tie- 2 mRNA and protein expression in stomach carcinomas and their adjacent normal mucosa. Microvessel density （MVD） was counted according to CD34 immunohistochemical staining. Results： There was positive expression of Angiopoietins/Tie-2 mRNA and protein in stomach carcinomas and their paired adjacent normal mucosa. It was found that correlation between Ang-1 protein, Tie-2 mRNA expression and MVD was negative （F=-0.440, F=-0.267; P〈0.05）, while the correlation between Ang-2 mRNA and its protein, Ang-2/Ang-1 protein ratio and MVD was positive （F=0.319, F=-729, F=739; P〈0.05）. Moreover, MVD in groups with Ang-2 mRNAT/N ratio over 1.2 （the ratio of Ang-2 mRNA in stomach carcinoma to its adjacent normal mucosa） was higher than those with the ratio under 1.2. Conclusion： It was suggested that Ang-1 and Ang-2 antagonizes in the angiogenesis and the anglogenesis in tumor ultimately depended on Ang-2/Ang-1 ratio, once the expression of Ang-2 is higher than Ang-1 in some degree, the angiogenesis in tumors was promoted, otherwise oppositely. In other words, Ang-2 plays dominant role in the action of angiogenesis in tumors.
|
| 关 键 词： | 表达 血管发生 胃癌 免疫组织化学 |
| 收稿时间： | 2006-09-07 |
| 修稿时间： | 2006-10-06 |
Angiopoietins/Tie-2 expression and angiogenesis in stomach carcinoma |
| |
| Zhenzhen Zhang,Sheng Zhang,Jianyin Lin,Peisheng Huang,Yupeng Chen.Angiopoietins/Tie-2 expression and angiogenesis in stomach carcinoma[J].The Chinese-German Journal of Clinical Oncology,2006,5(6):391-395. |
| |
| Authors: | Zhenzhen Zhang Sheng Zhang Jianyin Lin Peisheng Huang Yupeng Chen |
| |
| Affiliation: | (1) Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China;(2) Department of Molecular Biology, Fujian Medical University, Fuzhou, 350005, China;(3) Department of Pathology, Fujian Medical University, Fuzhou, 350005, China |
| |
| Abstract: | Objective To explore angiopoietins (Ang-1, Ang-2)/Tie-2 expression and angiogenesis in stomach carcinomas.
Methods RT-PCR and immunohistochemistry were used to detect angiopoietins/Tie-2 mRNA and protein expression in stomach carcinomas
and their adjacent normal mucosa. Microvessel density (MVD) was counted according to CD34 immunohistochemical staining.
Results There was positive expression of Angiopoietins/Tie-2 mRNA and protein in stomach carcinomas and their paired adjacent normal
mucosa. It was found that correlation between Ang-1 protein, Tie-2 mRNA expression and MVD was negative (r=−0.440, r=−0.267; P<0.05), while the correlation between Ang-2 mRNA and its protein, Ang-2/Ang-1 protein ratio and MVD was positive (r=0.319, r=729, r=739; P<0.05). Moreover, MVD in groups with Ang-2 mRNA T/N ratio over 1.2 (the ratio of Ang-2 mRNA in stomach carcinoma to its adjacent
normal mucosa) was higher than those with the ratio under 1.2.
Conclusion It was suggested that Ang-1 and Ang-2 antagonizes in the angiogenesis and the angiogenesis in tumor ultimately depended on
Ang-2/Ang-1 ratio, once the expression of Ang-2 is higher than Ang-1 in some degree, the angiogenesis in tumors was promoted,
otherwise oppositely. In other words, Ang-2 plays dominant role in the action of angiogenesis in tumors.
Supported by a grant from the Natural Sciences Foundation of Fujian (No. C0110013). |
| |
| Keywords: | angiopoietins (Ang-1 and Ang-2) tie-2 stomach neoplasm |
| 本文献已被 CNKI 维普 万方数据 SpringerLink 等数据库收录！ |
|
