| VEGF stimulates lymphangiogenesis in colorectal cancer and the treatment via anti-lymphangiogenesis |
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| 作者姓名： | 贡海兵 张国锋 范跃祖 |
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| 作者单位： | Department of Surgery Tongji Hospital，Tongji University，Shanghai 200065，China，Department of Surgery，Tongji Hospital，Tongji University，Shanghai 200065，China，Department of Surgery，Tongji Hospital，Tongji University，Shanghai 200065，China |
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| 摘 要： | Lymph node metastasis is the most common and basic way in the extending of colorectal tumor. It is an important reason for the difficulty of curing the tumor and the tumor's high mortality. And it is also an important factor that effects surgery treatment. Vascular endothelial growth factor( VEGF) family is a group of factors which specificly act on endothelial cell. VEGF has been shown to be an important regulator of tumour angiogenesis.but its effect on lymphan-giogenesis is not so clear. In this review, we discussed VEGF's effect on lymphangiogenesis, the colorectal microenviron-ment's effect on the factors expression and the therapeutics via antilymphangiogenesis by inhibiting VEGFR-3 signaling.
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| 关 键 词： | 结肠癌 直肠癌 淋巴 血管损伤 |
VEGF stimulates lymphangiogenesis in colorectal cancer and the treatment via anti-lymphangiogenesis |
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| Gong HaiBing;Zhang GuoFeng;Fan YueZu.VEGF stimulates lymphangiogenesis in colorectal cancer and the treatment via anti-lymphangiogenesis[J].China Medical Abstracts,2006,15(1):78-81,87. |
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| Authors: | Gong HaiBing;Zhang GuoFeng;Fan YueZu |
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| Affiliation: | Department of Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China |
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| Abstract: | Lymph node metastasis is the most common and basic way in the extending of colorectal tumor. It is an important reason for the difficulty of curing the tumor and the tumor's high mortality. And it is also an important factor that effects surgery treatment. Vascular endothelial growth factor( VEGF) family is a group of factors which specificly act on endothelial cell. VEGF has been shown to be an important regulator of tumour angiogenesis.but its effect on lymphan-giogenesis is not so clear. In this review, we discussed VEGF's effect on lymphangiogenesis, the colorectal microenviron-ment's effect on the factors expression and the therapeutics via antilymphangiogenesis by inhibiting VEGFR-3 signaling. |
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| Keywords: | lymphangiogenesis VEGF VEGFR metastasis |
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