| Protective effect of albumin on lung injury in traumatic/ hemorrhagic shock rats |
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| 引用本文： | 丁晨彦 陈作兵 郑树森 高原 张匀 赵雪红 倪玲美. Protective effect of albumin on lung injury in traumatic/ hemorrhagic shock rats[J]. 中华创伤杂志(英文版), 2005, 8(5): 317-320 |
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| 作者姓名： | 丁晨彦 陈作兵 郑树森 高原 张匀 赵雪红 倪玲美 |
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| 作者单位： | [1]The Department of Emergency Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China |
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| 基金项目： | This study was supported by the Research Foundation of Chinese Medicine Management Bureau, Zhejiang Province （ No. 2004C071 ） |
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| 摘 要： | Objective. To determine the effect of albumin administration on lung injury in traumatic/hemorrhagic shock （T/HS） rats. Methods： Forty-eight adult Sprague-Dawley rats were divided into three groups randomly （ n = 16 in each group） ： Group A, Group B, Group C. In Group A, rats underwent laparotomy without shock. In Group B, rats undergoing T/HS were resuscitated with their blood plus lactated Ringer＇s （twice the volume of shed blood ）. In Group C, rats undergoing T/HS were resuscitated with their shed blood plus additional 3 ml of 5% human albumin. The expression of polymorphonuclear neutrophils CD18/CD11b in jugular vein blood was evaluated. The main lung injury indexes （the activity of myeloperoxidase and lung injury score） were measured. Results： Significant differences of the expression of CD18/11b and the severity degree of lung injury were found between the three groups. （P〈0.05）. The expression of CD18/CD11b and the main lung injury indexes in Group B and Goup C incresed significantly compared with those in Group A （P 〈0.05）. At the same time, the expression of CD18/CD11b and the main lung injury indexes in Group C decreased dramatically, compared with those in Group B （ P 〈0.05 ）. Conclusions ： The infusion of albumin during resuscitation period can protect lungs from injury and decrease the expression of CD18/CD11b in T/HS rats.
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| 关 键 词： | 保护机制 白蛋白 肺损伤 出血性休克 小鼠 动物实验 |
Protective effect of albumin on lung injury in traumatic/ hemorrhagic shock rats |
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| Ding ChenYan;Chen ZuoBing;Zheng ShuSen;Gao Yuan;Zhang Yun;Zhao XueGong;Ni LingMei. Protective effect of albumin on lung injury in traumatic/ hemorrhagic shock rats[J]. Chinese journal of traumatology, 2005, 8(5): 317-320 |
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| Authors: | Ding ChenYan Chen ZuoBing Zheng ShuSen Gao Yuan Zhang Yun Zhao XueGong Ni LingMei |
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| Affiliation: | The Department of Emergency Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. |
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| Abstract: | OBJECTIVE: To determine the effect of albumin administration on lung injury in traumatic/hemorrhagic shock (T/HS) rats. METHODS: Forty-eight adult Sprague-Dawley rats were divided into three groups randomly (n=16 in each group): Group A, Group B, Group C. In Group A, rats underwent laparotomy without shock. In Group B, rats undergoing T/HS were resuscitated with their blood plus lactated Ringer's (twice the volume of shed blood). In Group C, rats undergoing T/HS were resuscitated with their shed blood plus additional 3 ml of 5% human albumin. The expression of polymorphonuclear neutrophils CD18/CD11b in jugular vein blood was evaluated. The main lung injury indexes (the activity of myeloperoxidase and lung injury score) were measured. RESULTS: Significant differences of the expression of CD18/11b and the severity degree of lung injury were founded between the three groups. (P<0.05). The expression of CD18/CD11b and the main lung injury indexes in Group B and Group C increased significantly compared with those in Group A (P<0.05). At the same time, the expression of CD18/CD11b and the main lung injury indexes in Group C decreased dramatically, compared those in Group B (P<0.05). CONCLUSIONS: The infusion of albumin during resuscitation period can protect lungs from injury and decrease the expression of CD18/CD11b in T/HS rats. |
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| Keywords: | Albumins Respiratory distresssyndrome, adult Traumatic/hemorrhagic shock |
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