| 枸杞多糖的抗肿瘤活性和对免疫功能的影响 |
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| 引用本文： | 甘璐,张声华.枸杞多糖的抗肿瘤活性和对免疫功能的影响[J].营养学报,2003,25(2):200-202,214. |
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| 作者姓名： | 甘璐 张声华 |
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| 作者单位： | 1. 华中科技大学化学系药物研究所,武汉,430074
2. 华中农业大学食品科技系,武汉,430070 |
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| 基金项目： | 湖北省自然科学基金 ( N o.95J2 5) |
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| 摘 要： | 目的 : 研究枸杞多糖 LBP-X的抗肿瘤效果及对荷瘤鼠免疫功能的调节作用。方法 : 采用小鼠 S1 80 实体瘤模型观察 LBP-X的体内抑瘤作用 ,并进行了免疫学指标测定。结果 : LBP-X具有明显的抗肿瘤活性 ,且可显著提高荷瘤鼠胸腺指数、巨噬细胞吞噬功能、脾细胞抗体形成、淋巴细胞转化反应、细胞毒性 T淋巴细胞杀伤功能及降低脂质过氧化值。结论 : LBP-X提高荷瘤鼠免疫功能是其抑制肿瘤效应的机制之一
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| 关 键 词： | 枸杞多糖 肿瘤抑制 免疫功能 |
| 文章编号： | 0512-7955(2003)02-0200-04 |
EFFECT OF LYCIUM BARBARUM POLYSACCHARIDE ON ANTITUMOR ACTIVITY AND IMMUNE FUNCTION |
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| GAN Lu,ZHANG Sheng hua.EFFECT OF LYCIUM BARBARUM POLYSACCHARIDE ON ANTITUMOR ACTIVITY AND IMMUNE FUNCTION[J].Acta Nutrimenta Sinica,2003,25(2):200-202,214. |
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| Authors: | GAN Lu ZHANG Sheng hua |
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| Affiliation: | GAN Lu,ZHANG Sheng hua 1 |
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| Abstract: | Objective: To study the antitumor effect of Lycium barbarum polysaccharide (LBP X) and its immunity regulating effect on S 180 bearing mice. Methods: S 180 bearing mice were used as animal model. The effect of LBP X on tumor weight and immune function was observed. Results: LBP X could inhibit the growth of S 180 effectively and increase thymus index, the macrophage phagocytic function, anti SRBC antibody secreted by the spleen cells, lymphocyte proliferation and CTL activity and decrease LPO markedly in S 180 bearing mice. Conclusion: The mechanism of tumor inhibition by LBP X was due to enhance the immune function. |
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| Keywords: | lycium barbarum polysaccharide tumor inhibition immune function |
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