| 置铜宫内节育器前后子宫内膜微血管密度及VEGF检测 |
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| 引用本文： | 辛志敏,孙莹璞,苏迎春,郭艺红,金海霞. 置铜宫内节育器前后子宫内膜微血管密度及VEGF检测[J]. 郑州大学学报(医学版), 2006, 41(3): 533-534 |
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| 作者姓名： | 辛志敏 孙莹璞 苏迎春 郭艺红 金海霞 |
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| 作者单位： | 郑州大学第一附属医院生殖医学中心,郑州,450052;郑州大学第一附属医院生殖医学中心,郑州,450052;郑州大学第一附属医院生殖医学中心,郑州,450052;郑州大学第一附属医院生殖医学中心,郑州,450052;郑州大学第一附属医院生殖医学中心,郑州,450052 |
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| 摘 要： | 目的:检测置铜宫内节育器(Cu-IUD)前后妇女子宫内膜组织中微血管密度(MVD)及血管内皮生长因子(VEGF)的变化.方法:免疫组化法检测10例放置Cu-IUD妇女置器前后子宫内膜VEGF的表达.以CD34标记血管内皮细胞,计数置器前后妇女子宫内膜MVD.结果:置器后子宫内膜VEGF的表达及MVD均高于置器前(P＜0.05),且2者的表达呈正相关(r=0.847,P＜0.05).结论:Cu-IUD可能通过促进妇女子宫内膜VEGF的表达,引起子宫内膜微血管结构和功能的改变,参与置器后异常出血的发生.
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| 关 键 词： | 血管内皮生长因子 微血管密度 宫内节育器 子宫内膜 |
| 收稿时间： | 2005-07-16 |
| 修稿时间： | 2005-07-16 |
Expression of microvessel density and VEGF in the endometrium of women wearing Cu-IUD |
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| XIN Zhimin,SUN Yingpu,SU Yingchun,GUO Yihong,JIN Haixia. Expression of microvessel density and VEGF in the endometrium of women wearing Cu-IUD[J]. Journal of Zhengzhou University: Med Sci, 2006, 41(3): 533-534 |
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| Authors: | XIN Zhimin SUN Yingpu SU Yingchun GUO Yihong JIN Haixia |
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| Affiliation: | Reproductive Medical Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 |
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| Abstract: | Aim: To investigate the expression of microvessel density (MVD) and VEGF in the endometrium of women wearing Cu IUD. Methods:Endometrial biopsy of 10 healthy women fit for experimental condition was performed on the same cycle day and the same spot before and after wearing the IUD for a month. The expression of VEGF and MVD in these biopsies were determined by immunohistochemical technique. Results: After wearing Cu IUD, the expression of VEGF and MVD were significantly higher than before (P<0.05). The expression of VEGF was positively correlated with MVD(r=0.847, P<0.05). Conclusion: Cu IUD may enhance the activity of VEGF in the endometrium of women, which may induce changes in the structure and function of endometrial blood vessle and result in abnormal uterine bleeding. |
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| Keywords: | VEGF MVD intrauterine device endometrium |
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