艾司西酞普兰与氟西汀治疗老年抑郁症的疗效与安全性对比观察

目的对比分析艾司西酞普兰与氟西汀治疗老年抑郁症的临床疗效与安全性,探讨老年抑郁症的合理治疗方法。方法将确诊为抑郁症的104例老年患者随机分为艾司西酞普兰组和氟西汀组,每组各52例,分别进行2个月的治疗,治疗前及治疗后2、4、8周进行汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、不良反应量表(TESS)评定两种药物的临床疗效与安全性。结果艾司西酞普兰组的总有效率为92.16%,氟西汀组的总有效率为82.15%,两组疗效比较差异无统计学意义(P>0.05);艾司西酞普兰组和氟西汀组的患者在治疗2周后的HAMD和HAMA评分差异有统计学意义,艾司西酞普兰组明显低于氟西汀组;而且艾司西酞普兰组治疗4、6周后HAMD评分也明显低于氟西汀组;氟西汀组出现乏力、便秘、恶心比例明显高于艾司西酞普兰组,差异有统计学意义。结论艾司西酞普兰较氟西汀更适合于老年期抑郁的治疗,抑郁和焦虑症状评分改善的时间更早,且安全性更好,可作为治疗老年抑郁症的首选药物。

The Comparative Analysis of Efficacy and Safety in the Treatment of Senile Depression by Escitalopram and Fluoxetine

Objective Make a comparative analysis of efficacy and safety in the treatment of senile depression by escitalopram and fluoxetine,and investigate the reasonable treatment of geriatric depression.Methods 104 elderly depression patients were randomly divided into escitalopram group and fluoxetine group,52 cases of each group,respectively,were treated for two months,the Hamilton Depression Rating Scale（HAMD）,Hamilton Anxiety Scale（HAMA）,side effects scale（TESS） were determined to assess the clinical efficacy and safety of two drugssex.Results The effective rate of the escitalopram group was 92.16%,the fluoxetine group was 82.15%,the clinical efficacy was not statistically significant（P 0.05）;There were statistically significant differences in HAMD and HAMA score between escitalopram group and fluoxetine group after two weeks of treatment,escitalopram was significantly lower than the fluoxetine group;the HAMD score of escitalopram group was significantly lower than the fluoxetine group after 4,6 weeks,the fatigue,constipation,nausea incidence of fluoxetine group was significantly higher than the escitalopram group,there was a statistically significant difference.Conclusion The escitalopram is more suitable for the treatment of senile depression,compared to fluoxetine,improve depression and anxiety faster,and have better security,can be used as the drug of choice of the treatment of depression.