| Synthesis and Crystal Structure of 7α-[（R）-1-Hy droxyl-1-methyl-3-（ thien-2-yl）-propyl]-6,14-endoethanotetrahydrothebaine |
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| 引用本文： | 刘河,刘春河,吴波,陈兰福,仲伯华.Synthesis and Crystal Structure of 7α-[（R）-1-Hy droxyl-1-methyl-3-（ thien-2-yl）-propyl]-6,14-endoethanotetrahydrothebaine[J].结构化学,2005,24(9):1021-1024. |
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| 作者姓名： | 刘河 刘春河 吴波 陈兰福 仲伯华 |
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| 作者单位： | No. 7 Department，Beijing Institute of Pharmacology and Toxicology，Beijing 100850，China，No. 7 Department，Beijing Institute of Pharmacology and Toxicology，Beijing 100850，China，No. 7 Department，Beijing Institute of Pharmacology and Toxicology，Beijing 100850，China，No. 7 Department，Beijing Institute of Pharmacology and Toxicology，Beijing 100850，China，No. 7 Department，Beijing Institute of Pharmacology and Toxicology，Beijing 100850，China |
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| 基金项目： | The project was supported by the NNSFC (No. 30271492) |
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| 摘 要： | 1 INTRODUCTION Opioid analogues still remain important drugs for the relief of severe pain and morphine is still the drug of choice in such situations. For many years, the search for new centrally acting opioid deriva- tives with pain-relieving properties and without un- desired side effects, such as addiction, obstipation, etc., has been the goal of a large number of scien- tists1-3]. Consequently, a wide variety of modifyca- tions of the well-known alkaloids morphine, codeine and thebai…
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| 关 键 词： | 蒂巴因 二甲基吗啡 结晶结构 合成方法 格利雅反应 |
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