质谱在新药研究中应用的回顾

回顾了质谱在新药研究中的一些应用 ,包括新药合成、化学结构确证、质量控制以及药物代谢物的鉴定等。综述了基质辅助激光解吸电离 \飞行时间质谱 ( Matrix-assistant laser desorption ionization time-of-flight mass spectrometry,MALDI/ TOFMS)、电喷雾电离质谱 ( Electrode spray ionization m ass spectrome-try,ESI-MS)等仪器及其联用技术在生物大分子药物研究 ,包括蛋白质组学、肽图谱、氨基酸序列、核苷酸分析等方面的进展 ,展望了质谱在未来生命科学中广阔的应用前景。

The Review of Mass Spectrometry Applied in New Drug Investigation

Some applications of mass spectrometry in new developing drugs investigation, including synthesis procedure, corroboration of chemical structure, quality control and drug metabolism are reviewed. The research progress of various instruments such as typical matrix-assistant laser desorption ionization time-of-flight mass spectrometry (MALDI/TOFMS), electrode spray ionization mass spectrometry (ESI-MS) and their technologies used together in biomacromolecule drugs, identification of protein, polypeptide, amino acid, DNA, RNA are summarized. Meanwhile, the broad prospects in mass spectrometry in living science are viewed.