5-Fu肠腔化疗辅助结直肠癌根治术的应用及其机制探讨

目的：探讨5-Fu肠腔化疗辅助结直肠癌根治术的应用及其机制。方法：总结我院1995年2月～2005年5月125例结直肠癌在根治术中辅助应用5-Fu肠腔化疗的临床资料。结果：本组125例无一例死亡，2例术后吻合口漏。经再次手术后治愈；96例随诊1～5年，失访29例，5年存活82例，其中并存肝转移者3例，骨转移者2例。5年生存率65．6％。结论：直肠癌根治术中辅助5-Fu肠腔化疗方法简便，效果明显，值得临床推广应用。

Discussion on the application and mechanism of the radical cure therapy against colon cancer and recta cancer with the subservient 5-Fu chemotherapy of intestines cavity

This paper aims to discuss the application and mechanism of the radical cure therapy against colon cancer and recta cancer with the subservient 5-Fu chemotherapy of intestines cavity.The method is as follows: to generalize clinic information of 125 cases of colon cancer and recta cancer from February,1995 to May,2005 in our hospital,which have adopted the radical cure therapy with subservient 5-Fu chemotherapy of intestines cavity.The result is as follows: no death in this 125-case group,2 cases anastomosis and complete cure after a second operation;96 cases for one-to-five year observation and treatment,29 cases losing contact.There are 82 cases of 5 years' survival,among which are 3 cases transferring to liver and 2 cases transferring to bones.The five-year survival rate is 65.6 %.The conclusion is as follows: this therapy is simple and with remarked effect,so it is worth popularizing in clinic.