亚硒酸钠的急性、蓄积性、亚急性毒性研究

目的：对常见的硒强化剂亚硒酸钠的毒性进行研究。方法：以Wistar大鼠为实验动物，分别采用改良寇氏法进行急性毒性实验，剂量递增法进行蓄积毒性实验，以1/20 LD50、1/10 LD50、1/5 LD50剂量连续灌胃30d进行亚急性毒性实验。系统研究亚硒酸钠对大鼠生长状况、组织病理变化、血常规、血液生化指标的影响。结果：大鼠经口灌胃亚硒酸钠的LD50为11.75mg/kg，蓄积系数为3.3，有中等蓄积毒性作用。0.588mg/kg剂量亚硒酸钠对大鼠生长有一定抑制作用，剖检及组织学变化以心、肝、脾、肺、肾等实质器官损伤为主，对主要器官脏器指数、血常规指标、血液生化指标均有不同程度影响。结论：亚硒酸钠属于高毒性物质，可以对大鼠造成急性、蓄积性、亚急性损伤。

Acute, Accumulative and Sub-acute Toxicity of Sodium Selenite

Objective: To explore the toxicity of sodium selenite.Methods: Wistar rats were used to explore acute toxicity and accumulative toxicity of sodium selenite by the modified Karber method and the dose-increasing method,respectively.In addition,rats administered with sodium selenite at doses of 1/20 LD50,1/10 LD50 and 1/5 LD50 for 30 consecutive days were used to explore its sub-acute toxicity.The growth status,histopathological change and blood biochemical indices of rats were determined.Results: The LD50 of ...