醛糖还原酶与炎症性疾病 |
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引用本文: | 李增玉,张焕萍.醛糖还原酶与炎症性疾病[J].中国当代医药,2012,19(16):17-18. |
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作者姓名: | 李增玉 张焕萍 |
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作者单位: | 1. 山西医科大学,山西太原,030001 2. 山西医科大学第一临床医学院呼吸内科,山西太原,030001 |
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摘 要: | 醛糖还原酶是多元醇通路的关键限速酶,以烟酰胺腺嘌呤二核苷磷酸(NADPH)为辅酶催化醛类或酮类物质还原为相应的醇,广泛存在于肾、肾上腺、睾丸、血管、胎盘、晶状体、视网膜、神经、心脏、脑、骨骼肌、肝等组织中。醛糖还原酶是脂质过氧化过程中产生醛类谷胱甘肽-醛聚合物解毒所必须的酶。醛糖还原酶除参与继发性糖尿病并发症外,还参与心血管疾病、肿瘤、败血症、葡萄膜炎及哮喘的气道炎症过程。
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关 键 词: | 醛糖还原酶 醛糖还原酶抑制剂 炎症 疾病 |
Aldose reductase and inflammatory diseases |
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Authors: | LI Zengyu ZHANG Huanping |
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Affiliation: | 1.Shanxi Medical University,Taiyuan 030001,China;2.Department of Respiration,First Affiliate Hospital of Shanxi Medical University,Taiyuan 030001,China |
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Abstract: | Aldose reductase is the key rate-limiting enzyme of the polyol pathway,and revert aldehydes or ketones to the corresponding alcohol by nicotinamide adenine dinucleotide phosphate(NADPH) as catalytic coenzyme.Aldose reductase widely present in the kidney,adrenal gland,testes,blood,placental,lens,retina,nerves,heart,brain,skeletal muscle,liver and other tissues.It’s a necessary detoxification enzyme that connected with the aldehyde-glutathione formaldehyde polymer in the process of lipid peroxidation.And that it is not only related to secondary diabetic complications,but also involved in cardiovascular diseases,cancer,sepsis,uveitis and airway inflammation in asthma. |
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Keywords: | Aldose reductase Aldose reductase inhibitors Inflammation Disease |
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