| 含有磺胺的多金属氧酸盐的合成及抑制前列腺癌细胞PC-3M作用的研究 |
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| 引用本文： | 刘霞,赵军,冯长根.含有磺胺的多金属氧酸盐的合成及抑制前列腺癌细胞PC-3M作用的研究[J].化学学报,2006,64(19):1988-1992. |
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| 作者姓名： | 刘霞 赵军 冯长根 |
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| 作者单位： | 1. 中国农业大学理学院,北京,100094
2. 北京理工大学新医药开发研究中心,北京,100081 |
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| 基金项目： | 中国工程物理研究院化工材料研究所资助项目. |
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| 摘 要： | 合成了(C6H9N2O2S)5HP2Mo18O62?15H2O (SPOM-1)和(C6H9N2O2S)H8P2Mo15V3O62?8H2O (SPOM-2)两种新的含有磺胺的多金属氧酸盐, 通过元素分析、IR光谱对其结构进行了表征. 在人雄激素非依赖性前列腺癌细胞系PC-3M内, 对合成的多金属氧酸盐进行了抗肿瘤活性的研究. 研究发现, SPOM-1, SPOM-2在体外能明显抑制前列腺癌PC-3M细胞, 并呈一定的量效关系, EC50分别为38, 11 g?mL－1; 治疗指数(TI)分别为12.07, 26.82; SPOM-2的抗前列腺癌PC-3M细胞活性大于SPOM-1.
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| 关 键 词： | 磺胺 多金属氧酸盐 抑制 前列腺癌 |
| 收稿时间： | 12 8 2005 12:00AM |
| 修稿时间： | 2005-12-082006-06-08 |
Studies on the Synthesis of Polyoxometalates Containing Sulfanilamide and Their Inhibition to Prostate Cancer Cell PC-3M |
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| LIU,Xia,ZHAO,Jun,FENG,Chang-Gen.Studies on the Synthesis of Polyoxometalates Containing Sulfanilamide and Their Inhibition to Prostate Cancer Cell PC-3M[J].Acta Chimica Sinica,2006,64(19):1988-1992. |
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| Authors: | LIU Xia ZHAO Jun FENG Chang-Gen |
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| Affiliation: | (College of Science, China Agricultural University, Beijing 100094)(Research and Development Center of New Medication, Beijing Institute of Technology, Beijing 100081) |
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| Abstract: | Two new polyoxometalates namely (C6H9N2O2S)5HP2Mo18O62?15H2O (SPOM-1) and (C6H9N2O2S)? H8P2Mo15V3O62?8H2O (SPOM-2) containing sulfanilamide were synthesized and structurally characterized by elementary analysis and IR spectra. The antitumor activities of these compounds had been investigated in human androgen independent prostate cancer cell PC-3M. SPOM-1 and SPOM-2 were shown to inhibit prostate cancer cell PC-3M significantly, and there was a certain dose-effect relationship. EC50 for the two samples was 38 and 11 μg?mL－1, respectively, and therapeusis index (TI) was 12.07 and 26.82, respectively. It was concluded from the test that the activity of SPOM-2 inhibiting prostate cancer cell PC-3M was superior to that of SPOM-1. |
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| Keywords: | sulfanilamide polyoxometalate inhibition prostate cancer |
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