| 眼眶成纤维细胞在甲状腺相关性眼病发病机制中的作用 |
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| 引用本文： | 段春青,孙斌.眼眶成纤维细胞在甲状腺相关性眼病发病机制中的作用[J].国际眼科纵览,2013(6):419-423. |
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| 作者姓名： | 段春青 孙斌 |
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| 作者单位： | 山西医科大学第三医院眼科,太原030053 |
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| 基金项目： | 山西省自然基金（2007011113;2013011059-2）;山西医科大学校青年基金（02201016） |
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| 摘 要： | 甲状腺相关性眼病的发病机制尚不十分明确.研究表明,此病发病过程中眼眶成纤维细胞既是自身免疫靶细胞,又是效应细胞,是其发病的关键因素.眼眶成纤维细胞自身抗体表达、氧化应激反应在甲状腺相关性眼病中起重要作用,通过对此方面的研究,探索对甲状腺相关性眼病有潜力的新的治疗方法.
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| 关 键 词： | 甲状腺相关性眼病 眼眶成纤维细胞 氧化应激 |
The role of orbital fibroblasts in the pathogenesis of thyroid-associated ophthalmopathy |
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| DUAN Chun-qing,SUN Bin.The role of orbital fibroblasts in the pathogenesis of thyroid-associated ophthalmopathy[J].International Review of Opthalmology,2013(6):419-423. |
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| Authors: | DUAN Chun-qing SUN Bin |
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| Affiliation: | ( Department of Ophthalmology, Shanxi Medical University of Third Hospital, Shanxi 030053, China) |
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| Abstract: | Pathogenesis of thyroid associated ophthahnopathy （TAO） is still unclear.Studies showed that orbital fibroblasts were not only the target cells but also the effector in the autoimmune response of TAO.The orbital fibroblasts,through their autoantibodies expression and oxidative stress reaction,might play the important role during the occurrence and development of TAO.Based on the relative studies,the new potential pathway of clinical pharmacotherapy for TAO may be explored. |
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| Keywords: | thyroid-associated ophthalmopathy orbital fibroblast oxidative stress |
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