| 反丁烯二酸单甲酯单酰氯的合成及催化性能 |
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| 引用本文： | 马冰洁,杨妍,唐洪波,董四清. 反丁烯二酸单甲酯单酰氯的合成及催化性能[J]. 精细化工中间体, 2010, 40(3): 50-52,63 |
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| 作者姓名： | 马冰洁 杨妍 唐洪波 董四清 |
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| 作者单位： | 沈阳工业大学,理学院,辽宁,沈阳,110178 |
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| 摘 要： | 以马来酸酐、甲醇和亚硫酰氯为原料,经酯化、异构化和酰氯化反应合成了反丁烯二酸单甲酯单酰氯(MMFC)。通过单因素和正交实验确定MMFC合成工艺条件为:n[反丁烯二酸单甲酯(MMF)]:n(亚硫酰氯)=1:2.5,反应温度100℃,反应时间50min。在优化条件下,MMFC收率可达91.99%。对MMFC异构化催化性能研究结果表明,MMFC是温和的MMF异构化催化剂,其异构化产物收率可达84.64%。
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| 关 键 词： | 反丁烯二酸单甲酯单酰氯 马来酸酐 正交实验 |
Synthesis of Monomethyl Fumarate Chloride and Its Catalytic Performance |
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| MA Bing-jie,YANG Yan,TANG Hong-bo,DONG Si-qing. Synthesis of Monomethyl Fumarate Chloride and Its Catalytic Performance[J]. Fine Chemical Intermediates, 2010, 40(3): 50-52,63 |
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| Authors: | MA Bing-jie YANG Yan TANG Hong-bo DONG Si-qing |
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| Affiliation: | (School of Science,Shenyang University of Technology,Shenyang 110178,China) |
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| Abstract: | Monomethyl fumarate chloride（MMFC） was synthesized in 91.99% yield by using maleic anhydride,methanol and thionyl chloride as starting materials in steps including esterification,isomerization and acyl chlorination.The optimum reaction conditions were obtained based on orthogonal experiments that molar ratio of monomethyl fumarate to SOCl2 1：2.5,reaction temperature 100℃,and reaction time 50 min.Studies showed that MMFC is a moderate catalyst for MMF isomerization in 84.64% yield. |
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| Keywords: | monomethyl fumarate chloride maleic anhydride orthogonal experiment |
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