Effect of histamine H1-receptor antagonist on the regulation of carbohydrate and lipid metabolism in rat liver |
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| Authors: | Y Koyama M Imoto M Tanaka Y Fukuda Y Miyazawa I Nakano T Ozawa |
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| Affiliation: | Department of Internal Medicine, Faculty of Medicine, University of Nagoya, Japan. |
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| Abstract: | In order to elucidate the role of histamine in the liver, we studied the effect of a histamine H1-receptor antagonist on the carbohydrate and lipid metabolism in the rat liver. The administration of the H1-receptor antagonist decreased significantly the contents of glycogen and malonyl-CoA in the liver. However, it did not affect the levels of serum glucose and free fatty acid. These results suggest that histamine may play a part in the regulation of metabolism of carbohydrates and lipids in the liver. |
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