幽门螺杆菌、胃泌素与慢性胃炎的关系

目的：对慢性浅表性胃炎（ＣＧＳ）患者行幽门螺杆菌（ＨＰ）及空腹血清胃泌素（ＳＧ）检测，对ＨＰ（＋）组和ＨＰ（－）组ＳＧ作对比，抗ＨＰ治疗前后ＳＧ、病理组织学作比较，探讨两者与ＣＳＧ的关系。方法：患者先行空腹作ＳＧ测定，再作胃镜检查，取胃罕粘膜３块，分另作快速尿素酶试验、Ｇｉｅｍｓａ染色及病理组织学检查。ＨＰ（＋）组抗ＨＰ治疗，１月后重复上述检查。结果：ＨＰ（＋）且ＳＧ明显高于ＨＰ（－）组（Ｐ〈０．

The Relationship Between Helicobacter Pyioric and Serum Gastrin in Chronic Superficial Gastritis

Purpose: To study the fasting serum gastrin (SG) level in patient with chronic superficial gastritis (CSG), which was divided into helicobacter pylori (HP) positive group and helicobacter pylori negative group. Methods: Fifty cases of CSG was diagnosticated by gastroscopy and be taked rapid ureas test, giemsa staining pathological examination on the histological biopsy from antral mucosa to differential cases in HP( ) group or HP(-) group. Than to repeat the same tests in HP still positive cases after a month of antibiotic therapy. Results: The SG level in HP( ) group was higher than HP(-) group significantly (P<0.05). After antibiotic therapy the SG level of HP still positive group also higher than the group in which HP have had conversed to negative and pathological examination was showed that the neutrophil infiltration of antral mucosa be decreased significantly. Conclusion: The infection of HP is the main causative agent in most cases of CSG. It stimulates the G cell to increase SG releasing being the major etiologic mechanism of CSG.