维甲酸自乳化制剂的含量测定及体外溶出评价 |
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引用本文: | 陆燕,全东琴.维甲酸自乳化制剂的含量测定及体外溶出评价[J].中国药物应用与监测,2004,1(2):57-59. |
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作者姓名: | 陆燕 全东琴 |
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作者单位: | 1. 北京积水潭医院,北京,100035 2. 军事医学科学院毒物药物研究所,北京100850 |
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摘 要: | 目的:研究维甲酸RA自乳化制剂的含量测定方法及体外溶出行为.方法:采用HPLC法测定维甲酸RA自乳化制剂的药物含量,与市售胶囊比较,考察RA自乳化制剂体外溶出行为.结果:与市售胶囊剂相比,以水为溶出介质,维甲酸RA自乳化制剂15min可以溶出80%以上,而市售胶囊只溶出不到5%.自乳化制剂可以显著提高药物的体外溶出.
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关 键 词: | 自乳化释药系统 药动学 体外溶出 |
文章编号: | 1672-8157(2004)02-0057-03 |
修稿时间: | 2004年5月30日 |
Drug content determination and dissolution evaluation of retinoid self - emulsifying drug delivery system in vitro |
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Authors: | LU Yan QUAN Dong-qin |
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Abstract: | Objective: To investigate the determination method and dissolution behavior of retinoid self - emulsifying drug delivery system in vitro. Method: Determine retinoid in self - emulsifying preparation by HPLC and evaluate dissolution behavior compared with market capsule. Result: Retinoid in self - emulsifying preparation dissolute 80% at 15min but 5% in market capsule. The self- emulsifying drug delivery system improved drug dissolution significantly. |
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Keywords: | SEDDS Pharmacokinetics Dissolution in vitro |
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