| Abstract: | 560 male albino mice were given a single training trial and then received either sham treatment or 4 ECS treatments at hourly intervals at 1 of 7 times (1–70 days) after training. Retention was always tested 2 wks after treatment. Controls exhibited gradual forgetting with increasing retention intervals. Ss given ECS exhibited severe retrograde amnesia, which diminished as the interval between training and ECS increased from 1 to 21 days. ECS given 21–70 days after training had no effect on memory. The finding of long, temporally graded retrograde amnesia in mice establishes continuity between the results for laboratory animals and those for humans and indicates that the neural changes involved in the consolidation of memory can continue for a significant portion of the lifetime of a memory. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) |
