| 不对称硼烷还原合成手性氨基醇 |
| |
| 引用本文： | 沈宗旋,李咏华,秦宏兵,张雅文.不对称硼烷还原合成手性氨基醇[J].化学研究,2004,15(3):23-26,49. |
| |
| 作者姓名： | 沈宗旋 李咏华 秦宏兵 张雅文 |
| |
| 作者单位： | 苏州大学,化学化工学院,江苏省有机合成重点实验室,江苏,苏州,215006;苏州大学,化学化工学院,江苏省有机合成重点实验室,江苏,苏州,215006;苏州大学,化学化工学院,江苏省有机合成重点实验室,江苏,苏州,215006;苏州大学,化学化工学院,江苏省有机合成重点实验室,江苏,苏州,215006 |
| |
| 摘 要： | 用原位生成的手性噁唑硼烷为催化剂,用2molBH3对1molα 或β 氨基酮进行了对映选择性还原,生成光学活性氨基醇 硼烷络合物,后者脱去BH3后给出光学活性氨基醇,ee值最高达99%.讨论了氨基酮结构与反应选择性的关系.
|
| 关 键 词： | 氨基醇 氨基酮 对映选择性还原 硼烷 |
| 文章编号： | 1008-1011(2004)03-0023-04 |
| 修稿时间： | 2004年3月5日 |
Synthesis of Chiral Amino Alcohols by Enantioselective Borane Reduction |
| |
| SHEN Zong-xuan,LI Yong-hua,QIN Hong-bing,ZHANG Ya-wen of Chemistry and Chemical Engineering,Suzhou University,Suzhou ,Jiangsu,China.Synthesis of Chiral Amino Alcohols by Enantioselective Borane Reduction[J].Chemical Research,2004,15(3):23-26,49. |
| |
| Authors: | SHEN Zong-xuan LI Yong-hua QIN Hong-bing ZHANG Ya-wen of Chemistry and Chemical Engineering Suzhou University Suzhou Jiangsu China |
| |
| Affiliation: | SHEN Zong-xuan,LI Yong-hua,QIN Hong-bing,ZHANG Ya-wen~* of Chemistry and Chemical Engineering,Suzhou University,Suzhou 215006,Jiangsu,China) |
| |
| Abstract: | A group of α- and β- dialkylaminoketones were reduced enantioselectively by using BH_3-THF and the in-situ formed chiral oxazaborolidine.The formed optically active aminoalcohol-borane complexes, which, after deboration gave optically active aminoalcohols with the ee up to 99%. The effects of the substrate structure on the enantioselectivity of the reaction were discussed. |
| |
| Keywords: | aminoalcohol aminoketone enantioselective reduction borane |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
