花生壳提取物对家兔血小板聚集的影响

目的:研究花生壳提取物体内、外给药对血小板活化因子(PAF)诱导家兔血小板聚集的影响。方法:分别采用体内和体外给药,比浊法测定血小板的聚集率,观察花生壳提取物对PAF诱导的家兔血小板聚集的抑制作用。结果:花生壳提取物在20、10mg·mL-1浓度下体外给药对PAF诱导血小板聚集有明显抑制作用(P<0.05),抑制率分别为47.13%、33.48%;在100mg·kg-1剂量下体内给药对PAF诱导血小板聚集有明显抑制作用(P<0.01),抑制率为21.78%。结论:花生壳提取物对PAF诱导的血小板聚集有抑制作用,其作用机制可能与拮抗PAF受体有关。

Effects of Extracts from Peanut Shell on Platelet Aggregation in Rabbit

OBJECTIVE：To study the effects of extracts from peanut shell on PAF-induced platelet aggregation in rabbit. METHODS： Rabbits were given PAF in vitro and in vivo. With turbidimetry, we tested platelet aggregation induced by PAF. The inhibition effect of extracts from peanut shell on PAF-induced platelet aggregation in rabbit was determined. RESULTS： The extracts of peanut shell inhibited platelet aggregation in vitro at the concentration of 20 mg·mL-1 and 10 mg·mL-1（P0.05）; inhibition rates were 47.13% and 33.48%. The extracts of peanut shell at the concentration of 100 mg·kg-1 also inhibited PAF-induced platelet aggregation in vivo;inhibition was 21.78%. CONCLUSION： Extract from peanut shell can inhibit PAF-induced platelet aggregation. and action mechanism is associate with PAF receptor.