复方硫磺洗剂与红霉素联合治疗痤疮的疗效观察

目的:观察复方硫磺洗剂与红霉素联合用药治疗痤疮的疗效。方法:100例痤疮患者按严重程度分为轻、中、重度,按双盲设计要求,随机分为2组,每组各50例:对照组给予外用复方硫磺洗剂,该洗剂由本院制剂室配制,处方配制按照《中国医院制剂规范》规定执行;治疗组给予外用复方硫磺洗剂联合红霉素,所用药物为每100mL复方硫磺洗剂加入6支红霉素无菌粉末(共1.5g)。4周为1疗程,每周复诊或随访1次,并观察记录患者粉刺、炎性丘疹、脓包和结节囊肿个数。结果:复方硫磺洗剂与红霉素联合治疗痤疮的总有效率(76%)明显高于对照组(38%),2组比较有显著性差异(P<0.05),且在治疗过程中不良反应发生率较低。结论:复方硫磺洗剂联合红霉素治疗痤疮疗效较好,副作用较少,且用药方便。

Efficacy Observation of Compound Sulfur Lotion Combined with Erythromycin in the Treatment of Acne

OBJECTIVE：To observe efficacy of compound sulfur lotion combined with erythromycin in the treatment of acne.METHODS：100 patients with mild,moderate and severe acne were randomly divided into control group（n=50） and treatment group（n=50）.Control group were treated with sulfur lotion for external use,and treatment group were given compound sulfur lotion and erythromycin for external use for 4 weeks.Each compound sulfur lotion 100 mL combined with 6 piece of erythromycin（a total of 1.5 g）.Return and follow-up visit were performed once a week.The number of acne,imflammatory papule,pustule,node cyst were observed and recorded.RESULTS：Total response rate of treatment group was 76%,which was significantly higher than that of control group（38%）.There were statistical difference between 2 groups（P0.05）.There was low incidence of ADR during treatment.CONCLUSION：Compound sulfur lotion combined with erythromycin shows sound effect on acne with few side effects and medication convenience.