| 抑郁症患者的多导联听觉P3a和P3b事件相关电位研究 |
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| 引用本文： | 李岳峙,刘铁榜,吴冬凌. 抑郁症患者的多导联听觉P3a和P3b事件相关电位研究[J]. 中国医学物理学杂志, 2008, 25(6): 921-925 |
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| 作者姓名： | 李岳峙 刘铁榜 吴冬凌 |
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| 作者单位： | 1. 深圳大学机电学院,深圳,广东,518060
2. 深圳市康宁医院,深圳,广东,518020 |
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| 摘 要： | 目的：研究抑郁症患者的16导联听觉事件相关电位P300的脑区强度分布。方法：选择抑郁症患者27例和正常人30名，用脑诱发电位仪记录受试者16导事件相关电位P3a和P3b，分析受试者在额区、颞区、中央区和顶区的P300幅度分布，比较抑郁症患者和正常对照组的显著差异。结果：抑郁症患者的P3a、P3b幅度的额区／顶区比值较正常对照组都发生显著降低（P〈0．01），颞区／顶区比值也显著降低（P〈0．01），中央区／顶区比值同样显著降低（P〈0．01），另外，抑郁症患者的额1区／额2区P3b幅度比值显著降低。结论：通过多导联记录P300，并分析P300幅度在脑区间的相对强弱关系，将能获得抑郁症患者的异常ERPs特征，并能提示主要相关脑区的功能状况，因此，有助于提高P300诊断抑郁症的特异性水平。
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| 关 键 词： | 抑郁症 P3A P3B 三音oddball模式 |
Study of Multiple Channels Auditory P3a and P3b Potentials in Patients with Depressive Disorder |
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| LI Yue-zhi,LIU Tie-bang,WU Dong-ling. Study of Multiple Channels Auditory P3a and P3b Potentials in Patients with Depressive Disorder[J]. Chinese Journal of Medical Physics, 2008, 25(6): 921-925 |
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| Authors: | LI Yue-zhi LIU Tie-bang WU Dong-ling |
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| Affiliation: | LI Yue-zhi1,LIU Tie-bang2,WU Dong-ling2 (1. College of mechatronics , control engineering,Shenzhen university,Shenzhen Guangdong 518060,China,2. Shenzhen kang-ning hospital,Shenzhen Guangdong 518020,China) |
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| Abstract: | Objectives: To study the potential distribution in the brain regions with 16 channels auditory event related poten-tial P300 recordings in patients with depressive disorder. Methods: 28 patients with depressive disorder and 30 healthy con-trols were recruited. 16 channels event related potential P3a and P3b were collected in all the subjects, P300 amplitudes dis-tribution in frontal, temporal, central and parietal regions were analyzed and the difference between depressive disorder and healthy control was i... |
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| Keywords: | P3a P3b |
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