Stimulation by volume expansion of atrial natriuretic peptide release from perfused rat heart |
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| Authors: | Y Kabayama Y Fukamachi T Kamisaki H Tanaka |
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| Affiliation: | 1. Department of Environmental and Preventive Medicine, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan;2. Department of Cardiovascular Surgery, Yamagata Saisei Hospital, Yamagata, 990-8545, Japan;3. Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Japan;4. Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan;1. Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464–8601, Japan;2. Department of Neural Regulation, Nagoya University Graduate School of Medicine, Nagoya 466–8550, Japan;3. JSPS Postdoctoral Fellowships for Research in Japan;4. Chinese Institute for Brain Research, Beijing (CIBR), Beijing 102206, China;5. National Institute for Physiological Sciences, National Institutes of Natural Sciences, Aichi 444–8585, Japan;6. Division of Brain Sciences Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160–8582, Japan |
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| Abstract: | The release of immunoreactive (ir-) rat atrial natriuretic peptide (rANP) with volume expansion in in situ retrograde perfused rat heart was examined. The volume expansion induced by the infusion of the perfusion medium into the right atrium increased the mean right atrial pressure and the ir-rANP release without changing the rate of the heart beat. There was a significant correlation between the peak values of ir-rANP release and those of mean atrial pressure. The bilateral cervical vagotomy did not effect the ir-rANP release induced by the volume expansion. Therefore, it is highly likely that the stimulatory effect of volume expansion on rANP release is due to, at least in part, the atrial distension accompanied by an increase in mean atrial pressure, not involving a vagal system. |
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