血浆同型半胱氨酸水平与腹主动脉瘤的相关性研究

目的探讨血浆同型半胱氨酸(Hcy)水平与腹主动脉瘤的相关性。方法回顾性分析2011年7月²012年7月入住我院血管外科经CT诊断为腹主动脉瘤患者(病例组)58例,另选健康体检者63例为对照组。常规检测血生化指标,采用循环酶法检测Hcy水平。结果与对照组比较,病例组高同型半胱氨酸血症(HHcy)发生率明显升高(65.5%vs 27.0%,P<0.01),Hcy水平明显升高[(19.02±9.80)μmol/L vs(13.37±4.54)μmol/L,P<0.01]。多元logistic回归分析显示,HHcy较非HHcy发生腹主动脉瘤的风险增加4.12倍(OR=5.12,95%CI:2.332012年7月入住我院血管外科经CT诊断为腹主动脉瘤患者(病例组)58例,另选健康体检者63例为对照组。常规检测血生化指标,采用循环酶法检测Hcy水平。结果与对照组比较,病例组高同型半胱氨酸血症(HHcy)发生率明显升高(65.5%vs 27.0%,P<0.01),Hcy水平明显升高[(19.02±9.80)μmol/L vs(13.37±4.54)μmol/L,P<0.01]。多元logistic回归分析显示,HHcy较非HHcy发生腹主动脉瘤的风险增加4.12倍(OR=5.12,95%CI:2.33¹1.27,P=0.00)。调整相关危险因素后,未明显改变相关结果(OR=3.35,95%CI:1.1411.27,P=0.00)。调整相关危险因素后,未明显改变相关结果(OR=3.35,95%CI:1.14⁹.80,P=0.03)。病例组HHcy患者与Hcy水平正常者腹主动脉瘤最大直径比较,差异无统计学意义[(5.66±1.49)cmvs(5.11±0.98)cm,P=0.18],年龄与腹主动脉瘤最大直径不相关(r=0.09,P=0.48)。结论 HHcy患者发生腹主动脉瘤的风险更大。降低Hcy水平可能有助于减缓腹主动脉瘤的发展。

Correlation between plasma homocysteine level and abdominal aortic aneurysm

Objective To study the correlation between plasma homocysteine(Hcy)level and abdominal aortic aneurysm(AAA).Methods Fifty-eight AAA patients admitted to our department from July 2011to July 2012served as an AAA group and 63subjects undergoing physical examination served as a control group in this study.Their plasma Hcy levels were measured by immunoassay.Results The incidence of HHcy and the plasma Hcy level were higher in AAA group than in control group(65.5%vs 27.0%,P<0.01;13.37±4.54μmol/Lvs 19.02±9.80μmol/L, P<0.01).Multivarite logistic regression analysis showed that the risk to develop AAA was 4.12-fold higher in HHcy patients than in non-HHcy patients(OR=5.12,95%CI:2.33-11.27,P= 0.00).No significant change was observed after adjustment for relavent risk factors(OR=3.35, 95%CI:1.14-9.80,P=0.03).No significant difference was found in diameter of AAA in HHcy patients with normal plasma Hcy level(5.66±1.49cmvs5.11±0.98cm,P=0.18).The age was not related with the diameter of AAA(r=0.09,P=0.48).Conclusion The risk to develop AAA is higher in HHcy patients.Reducing plasma Hcy level can help to slow down the progression of AAA.