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Hyperbranched Conjugated Polyelectrolyte for Dual‐modality Fluorescence and Magnetic Resonance Cancer Imaging |
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| Authors: | Dan Ding Guan Wang Jianzhao Liu Kai Li Kan‐Yi Pu Yong Hu Jason C. Y. Ng Ben Zhong Tang Bin Liu |
| Affiliation: | 1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore;2. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China;3. Institute of Materials Research Engineering, 3 Research Link, 117602, Singapore;4. National Laboratory of Solid‐State Microstructure, Department of Material Science and Engineering, Nanjing University, Nanjing 210093, China |
| Abstract: | Herein is reported the synthesis of gadolinium ion (Gd(III))‐chelated hyperbranched conjugated polyelectrolyte (HCPE‐Gd) and its application in fluorescence and magnetic resonance (MR) dual imaging in live animals. The synthesized HCPE‐Gd forms nanospheres with an average diameter of ～42 nm measured by laser light scattering and a quantum yield of 10% in aqueous solution. The absorption spectrum of HCPE‐Gd has two maxima at 318 and 417 nm, and its photoluminescence maximum centers at 591 nm. Confocal laser scanning microscopy studies indicate that the HCPE‐Gd is internalized in MCF‐7 cancer cell cytoplasm with good photostability and low cytotoxicity. Further fluorescence and MR imaging studies on hepatoma H22 tumor‐bearing mouse model reveal that HCPE‐Gd can serve as an efficient optical/MR dual‐modal imaging nanoprobe for in vivo cancer diagnosis. |
| Keywords: | conjugated polyelectrolytes hyperbranched polymers fluorescence imaging magnetic resonance imaging in vivo imaging |
