梨状窝癌手术前后放疗与喉功能保全

目的探讨梨状窝鳞状细胞癌(简称梨状窝癌)手术前或手术后放疗与喉功能保全治疗的效果。方法回顾性分析1985年9月—2001年7月收治的梨状窝鳞状细胞癌134例。术前放射治疗+手术治疗(简称R+S)100例,手术+术后放疗(简称S+R)34例。随访中位时间38.1个月。结果根据KaplanMeier方法统计R+S组与S+R组3年生存率分别为54.8%、50.1%,5年生存率分别为51.1%、45.9%,差异均无统计学意义(P>0.05)。T1、T2、T3和T4期患者在R+S组与S+R组喉功能保留情况分别为4/5、3/3,66.7%(32/48)、6/6,32.4%(12/37)、0(0/16)和0(0/10)、0/9,其中T3期喉功能保留率R+S组较高,与S+R组的差异有统计学意义(P<0.05),其喉功能保留与丧失在局部复发、生存率等相关因素差异无统计学意义。R+S组和S+R组术后大体标本切缘阳性率为7.0%(7/100)和20.6%(7/34),两者差异有统计学意义(P<0.05)。Cox多因素变量分析切缘阳性、临床N分期对预后呈明显相关(P值均<0.05)。结论计划性术前放疗与术后放疗在下咽梨状窝癌的治疗上具有相同疗效。声门旁间隙受侵的T3病例选择R+S治疗可以提高喉功能的保留率,不增加预后的风险。R+S治疗方式切缘阳性率低,对喉功能的保留提供可靠客观依据。临床N分期对预后影响很大,是综合治疗的难点。

Result analysis of perioperative radiotherapy and laryngeal preservation in hypopharyngeal and pyriform sinus squamous cell carcinoma

OBJECTIVE: To evaluate perioperative radiotherapy and laryngeal preservation clinical result of hypopharyngeal pyriform sinus squamous cell carcinoma. METHODS: A retrospective review was undertaken of 134 pyriform sinus squamous cell carcinoma cases who were treated at this institute in Department of Head and Neck Surgery from September 1985 to July 2001. One hundred patients received preoperative radiotherapy and surgery (R + S). Thirty-four patients received surgery and postoperative radiotherapy (S + R). The median follow-up interval was 38.1 months. RESULTS: (R + S) and (S + R) group 3-year and 5-year survival according to Kaplan-Meier were 54.8%, 50.1%; 51.1%, 45.9% respectively, and had no significant differences (all P > .05). The laryngeal function preservation of T1, T2, T3, T4 in (R +S) and (S + R) were 4/5, 3/3; 66.7% (32/48), 6/6; 32.4% (12/37), 0 (0/16); 0 (0/10), 0/9 respectively. T3 stage in (R + S) was good and significant different than in (S + R) (P < 0.05) and laryngeal preservation didn't increase hazard of survival and local recurrence. The two group Pathology( + ,P + ) in specimen margin were 7.0% (7/100); 20.6% (7/34) and had significant difference (P <0. 05). P + in specimen margin and clinical N stage are obvious interrelated in prognosis(P < 0. 05). CONCLUSIONS: Combined therapy (R + S) and (S + R) are equal in treat result. T3 (only paraglottic space is invaded) stage of (R + S) could increase preserved laryngeal ratio if condition is permitted and didn't add hazard. P + in specimen margin could be receded in (R + S) and profit to prognosis and function. Clinical N stage is obvious hazard and is an emphasis in combined therapy.