632例泌尿生殖道支原体的检测及药敏分析

目的研究泌尿生殖道感染患者支原体检测情况及耐药状况。方法应用支原体培养鉴定药敏试剂盒对泌尿生殖道感染者的标本做体外支原体培养鉴定和药敏试验。结果632例患者共检出支原体感染285例，其中解脲脲原体（Uu）阳性200例（31．65％），显著高于人型支原体（Mh）感染（33例，占5．22％）及Uu＋Mh混合感染（52例，占8．23％）（P〈O．01）；单纯Uu感染药敏试验耐药率较低的4种抗生素分别是交沙霉素、强力霉素、原始霉素及克拉霉素，其耐药率分别为2，00％、2．50％、4．00％及13．00％，对氧氟沙星及环丙沙星耐药率最高，分别达到70．50％及69．50％，而Mh及Uu＋Mh混合感染耐药率明显高于单纯Uu感染者。结论泌尿生殖道支原体检测及耐药性监测，对于指导临床治疗，控制耐药菌株的产生具有重要意义。

Detection and drug sensitivity analysis of mycoplasma in genitourinary tract of 632 patients with mycoplasma infection

Objective To investigate the infection status and drug resistance of mycoplasmal in genitourinary tract of patients with mycoplasma infection. Methods The integration kit was adopted to perform mycoplasma culture, identification and drug sensitivity test for species from 632 patients with mycoplasma infection. Results Of all 632 patients, 285 cases were with myeoplasma infection, in which 200 cases (31.65%) were Ureaplasma urealyticum (Uu) positive, 33 cases (5.22%) were my- eoplasam hominis (Mh) positive, and 52 cases (8. 23%) were with mixed infection of Uu and Mh. The simple Uu infection had lower drug resistance against four antibiotics such as josamyein, doxycye- line, pristinamyein and elarithromycin, 2.00%, 2.50%, 4.00% and 13.00% respectively. However, it had higher drug resistance against ofloxaein and ciprofloxacin, 70. 50% and 69. 50% respectively. The resistance rate of Mh infection as well as mixed infection of Uu and Mh was much higher than that of simple Uu infection. Conclusion The detection and drug sensitivity monitoring of mycoplasma play an important role in guiding clinical treatment and controlling the production of drug resistant strains.