Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship |
| |
| Authors: | Boumendjel Ahcène Boccard Julien Carrupt Pierre-Alain Nicolle Edwige Blanc Madeleine Geze Annabelle Choisnard Luc Wouessidjewe Denis Matera Eva-Laure Dumontet Charles |
| |
| Affiliation: | Département de Pharmacochimie Moléculaire, UMR 5063, ICMG-FR 2607-Université Joseph Fourier Grenoble I, 470 rue de la Chimie, 38240 St Martin d'Hères, France. ahcene.boumendjel@ujf-grenoble.fr |
| |
| Abstract: | A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
