2,3,5,6-tetramethylmorpholine. VI. Cyclization of N-substituted 3,3′-iminobis-2-butanols |
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Authors: | Sven Hernestam Gillis Stenvall |
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Abstract: | The cyclization of N-substituted 3,3′-iminobis-2-butanols to N-substituted 2,3,5,6-tetramethylmorpholines in sulfuric acid is studied. The ring closure seems to be exclusively a normal SN2-type substitution with partial inversion of configuration before the cyclization. The steric influence of the N-substituents on the SN2-reaction and on the inversion is discussed. |
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