骨灵膏及拆方制剂治疗骨性关节炎

目的:探讨骨灵膏及拆方制剂骨膏、灵膏对骨性关节炎的临床疗效,确定膏剂疗效最优组方配伍方式。方法:实验分为3组,采用骨灵膏(Guling gao,GLG)、骨膏(Gu gao,GUG)、灵膏(Ling gao,LG)治疗骨性关节炎(osteoarthritis,OA)患者153例,每组51例;按照视觉模拟评分法(visual analogous scale,VAS)、Lysholm膝关节功能评分(Lysholm kneescore,LKSS)等标准判定比较各组疗效。结果:各治疗组均能很好改善VAS及LKSS评分,降低关节肿胀及活动指数,骨灵膏较骨膏、灵膏更明显(P<0.05);骨灵膏的疗效明显优于骨膏和灵膏组(P<0.05)。结论:骨灵膏与其拆方配伍制剂骨膏、灵膏比较,在治疗膝关节骨性关节炎方面疗效显著,提示以"脏病、络病"为指导思想联合组方配伍优于拆方。

Guling Gao and its Components in Treatment of Osteo-arthritis

Objective:To study effect of Guling gao(GLG) and its components like Guo Gao(GUG),Ling Gao(LG) on osteoarthritis and determine the efficacy of optimal compatibility. Method: Experiment was divided into 3 groups,GLG, GUG and LG group for treatment of osteoarthritis(OA)in 153 cases,51 cases in each group; according to the visual analog scale(VAS),Lysholm knee function scores (LKSS) and other criteria were used to compare efficacy. Result: The treatment group greatly improved the VAS and LKSS score,reduce joint swelling and activity index,GLG, compared with GUG and LG group, was more obvious(P<0.05). Conclusion: GLG, compared with GUG and LG,has notablely curative effect in treatment of knee osteoarthritis.