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A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring |
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| Authors: | Sandra GemmaStefania Butini Caterina FattorussoIsabella Fiorini Vito NacciKatherine Bellebaum Down McKissicAshima Saxena Giuseppe Campiani |
| Affiliation: | a Dipartimento Farmaco Chimico Tecnologico, Universita' di Siena, via Aldo Moro, 53100 Siena, Italy b Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy c Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA |
| Abstract: | The synthesis of two new Huperzine A analogues is reported. Both products present an amino substituted benzo-fused system in place of the pyridone ring of the natural alkaloid. The synthetic strategy to the two analogues is based on three different key palladium-catalyzed steps, namely a carbonylation reaction, an epoxide isomerization and a bicycloannulation reaction. |
| Keywords: | palladium carbonylation epoxide isomerization bicycloannulation reaction |
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