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Stereoselective reduction of arteannuin B and its chemical transformations |
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| Authors: | Asish K Bhattacharya Mahesh PalDharam C Jain Bhawani S JoshiRaja Roy Urszula RychlewskaRam P Sharma |
| Affiliation: | a Phytochemical Technology Division, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226 015, India b RSIC Division, Central Drug Research Institute, Lucknow 226 001, India c Faculty of Chemistry, A. Mickiewicz University, 60-780 Poznan, Poland d Department of Chemistry, Lucknow University, Lucknow 226 007, India |
| Abstract: | Absolute stereochemistry of dihydroarteannuin B 5 obtained by the reduction of arteannuin B 3 with Ni2B, NaBH4 or CdCl2-Mg-MeOH-H2O has been established by 2D NMR and single crystal X-ray diffraction studies. Some experiments aimed at the synthesis of dihydrodeoxyarteannuin B [C-4, 5 double bond isomer of 11] are also discussed. |
| Keywords: | Artemisia annua antimalarial artemisinin arteannuin B chemical transformations |
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