| 2,5-呋喃二甲酸的合成 |
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| 引用本文： | 刘浪,杨顺利,李鸿波. 2,5-呋喃二甲酸的合成[J]. 精细化工, 2011, 28(4): 410-412 |
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| 作者姓名： | 刘浪 杨顺利 李鸿波 |
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| 作者单位： | 1. 西南科技大学,材料科学与工程学院,四川,绵阳,621010
2. 凯新化学有限公司,四川,绵阳,621000 |
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| 基金项目： | 四川省科技厅项目，西南科技大学引进人才项目 |
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| 摘 要： | 以糠酸为原料,经过酯化、氯甲基化、水解、氧化得到2,5-呋喃二甲酸,并对各步反应中的工艺参数进行了优化。优化结果:酯化反应时间为10 h,氯甲基化反应温度为35～40℃,水解反应原料摩尔比为n(氢氧化钠)∶n(5-氯甲基-2-呋喃甲酸甲酯)=2.1∶1,氧化反应体系pH=7～8,反应总收率47.5%。按该工艺顺利完成了3次20 L扩试反应,平均收率可达47.3%,产品HPLC纯度大于99.4%。
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| 关 键 词： | 糠酸 2,5-呋喃二甲酸 5-氯甲基-2-呋喃甲酸甲酯 精细化工中间体 |
| 收稿时间： | 2010-11-18 |
| 修稿时间： | 2010-12-28 |
Synthesis of furan-2,5-dicarboxylic acid |
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| LIU Lang,YANG Shun-li and LI Hong-bo. Synthesis of furan-2,5-dicarboxylic acid[J]. Fine Chemicals, 2011, 28(4): 410-412 |
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| Authors: | LIU Lang YANG Shun-li LI Hong-bo |
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| Affiliation: | Southwest University of Science and Technology,Chemget Chemical Co. LTD,Southwest University of Science and Technology |
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| Abstract: | Furan-2,5-dicarboxylic acid was synthesized from furoic acid through esterification,chloromethylation,hydration and oxidation,and the important process parameters in each step were also optimized.The optimal reaction conditions were obtained as follows:the time of esterification was 10 hours,the temperature of chloromethylation was 35～40 ℃ n(sodium hydroxide)∶n(methyl 5-chloromethyl-furan-2-carboxylate)=2.1∶1 in hydration,pH=7～8 in oxidation,the total yield was 47.5%.Under the optimized conditions,the synthetic method of furan-2,5-dicarboxylic acid was successfully carried out three times in 20 L reactor and the average yield could reach 47.3%,and the purity of the product was over 99.4%. |
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| Keywords: | furoic acid furan-2,5-dicarboxylic acid synthesis |
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