Allergenic glaucans from dermatophytes. II. Enzymic degradation |
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Authors: | M J How M T Withnall P J Somers |
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Affiliation: | Groupe de chimie organique 1, Bâtiment 6, Ensemble Universitaire des Cézeaux, Université de Clermont-Ferrand, 63170-Aubière France |
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Abstract: | The action of pyruvic acid on glycerol leads principally to two isomeric, bicyclic lactones 1 and 2; this reaction is compared with that employing methyl and ethyl esters of pyruvic acid. The action of pyruvaldehyde or 2,3-butanedione on glycerol leads to bicyclic heterocycles having a secondary (5) or tertiary (6) hemiacetal group, respectively. These compounds, and likewise the derived alkoxy, acetoxy, and chloro analogs, are subject to the anomeric effect, the endo isomers being thermodynamically more stable than the exo isomers. |
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