| 6-去氢诺龙醋酸酯的合成 |
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| 引用本文： | 张同斌,陈宏博,郑承钢.6-去氢诺龙醋酸酯的合成[J].中国药业,2006,15(15):29-30. |
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| 作者姓名： | 张同斌 陈宏博 郑承钢 |
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| 作者单位： | 大连理工大学精细化工国家重点实验室,辽宁,大连,116024 |
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| 摘 要： | 目的 以相对廉价的19-去甲-4-雄烯二酮为起始原料合成6-去氢诺龙醋酸酯。方法 经醚化、还原、双酯化和脱氢4个操作步骤合成目标化合物。结果 革除文献中用到的有毒溶剂苯，以硼氢化钾替代了价格贵且易潮解的硼氢化钠，降低了成本；用亚硫酸氢钠破坏反应中过剩的N-溴代丁二酰亚胺（NBs），从而提高了产品质量；总收率为51％。结论 用该方法合成6-去氢诺龙醋酸酯，收率高，成本低，适宜于工业化生产。
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| 关 键 词： | 19-去甲-4-雄烯二酮 6-去氢诺龙醋酸酯 合成 |
| 文章编号： | 1006-4931(2006)15-0029-02 |
| 收稿时间： | 07 28 2006 12:00AM |
| 修稿时间： | 2006年7月28日 |
Improved Synthesis of 6-dehydronandrolone Acetate |
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| Zhang Tongbin,Chen Hongbo,Zheng Chenggang.Improved Synthesis of 6-dehydronandrolone Acetate[J].China Pharmaceuticals,2006,15(15):29-30. |
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| Authors: | Zhang Tongbin Chen Hongbo Zheng Chenggang |
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| Affiliation: | State Key Laboratory of Fine Chemistry, Dalian bniversity of Science and Engineering, Dalian, Liaoning, China 116024 |
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| Abstract: | Objective To synthesize 6- dehydronandrolone ac.etate by starting from 19-nor-4- androsten- 3, 17- dione. Methods The target compound was got by ethertation, reduction, diestation and dehydronation. Results Poisonous benzene was changed into chloroform and the expensive sodium borohydride was replaced with potassium borohydride. At the same time, the superfluous NBS was get rid of by adding sodium bisulfite;the total yield was 51%. Conclusion The purity of the product is improved and the cost of production is reduced. This method is optimized to industrialization. |
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| Keywords: | 19 - nor - 4 - androsten - 3 17 - dione 6 - dehydronandrolone synthesis |
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