| 乙型肝炎血源疫苗不同免疫剂量阻断新生儿母婴传播的效果观察 |
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| 引用本文： | 沙庆洪,刘玉霞,刘家壁,徐勇,荆庆,彦天强,徐志一,刘崇柏. 乙型肝炎血源疫苗不同免疫剂量阻断新生儿母婴传播的效果观察[J]. 病毒学报, 1991, 0(Z1) |
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| 作者姓名： | 沙庆洪 刘玉霞 刘家壁 徐勇 荆庆 彦天强 徐志一 刘崇柏 |
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| 作者单位： | 广东省卫生防疫站(沙庆洪，刘玉霞，刘家壁，徐勇)，河南省开封市肝病研究所(荆庆)，湖南省湘潭市卫生防疫站(彦天强)，上海医科大学流行病教研室(徐志一)，中国预防医学科学院病毒学研究所(刘崇柏) |
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| 摘 要： | 用乙型肝炎血源疫苗,按0、1、6程序,分5种不同剂量免疫HBsAg和HBeAg均阳性(双阳性)母亲和仅HBsAg阳性母亲的新生儿,井于首针后8～12个月采血,用放射免疫(RIA)法检测他们的HBsAg和抗-HBs、抗-HBc,以比较不同剂量乙肝疫苗阻断母婴传播的效果。结果,10μg×3组对双阳性和仅HBsAg阳性母亲的新生儿的保护率,分别是42.9％和53.5％;20μ×3组为67.4％和69.7％;30μg、10μg、10μg组为75.6％和79.8％,30.20、20μg(含30、30、10μg)组为80.2％和81.5％;30μg×3组为82.3％和83.7％。随疫苗剂量增加保护率逐渐增加,抗-HBs阳转率也是如此。
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| 关 键 词： | 乙型肝炎血源疫苗 母婴传播 保护率 |
PREVENTION OF PERINATAL TRANSMISSION OF HEPATITIS B VIRUS(HBV) BY USING VARIOUS DOSES OF PLASMA-DERIVED HEPATITIS B VACCINE |
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| Sha Qinghong Liu Yuxia Liu JiabiXu Yong Jing Qing Yan TianqiangXu Zhiyi Liu Chongbai Sanitation and Anti-epidemic Station of Province Guangdong,Guangzhou Institute of Hepatopathy of City Kaifeng,Henan Sanitation and Anti-epidemic Station of City Xiangtan,Hunan. PREVENTION OF PERINATAL TRANSMISSION OF HEPATITIS B VIRUS(HBV) BY USING VARIOUS DOSES OF PLASMA-DERIVED HEPATITIS B VACCINE[J]. Chinese journal of virology, 1991, 0(Z1) |
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| Authors: | Sha Qinghong Liu Yuxia Liu JiabiXu Yong Jing Qing Yan TianqiangXu Zhiyi Liu Chongbai Sanitation Anti-epidemic Station of Province Guangdong Guangzhou Institute of Hepatopathy of City Kaifeng Henan Sanitation Anti-epidemic Station of City Xiangtan Hunan |
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| Affiliation: | Sha Qinghong Liu Yuxia Liu JiabiXu Yong Jing Qing Yan TianqiangXu Zhiyi Liu Chongbai Sanitation and Anti-epidemic Station of Province Guangdong,Guangzhou Institute of Hepatopathy of City Kaifeng,Henan Sanitation and Anti-epidemic Station of City Xiangtan,Hunan Department of Epidemiology,Shangnai Medical Univertity Institute of Virology,Chinete Academy of Preventive Medicine,Beijing |
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| Abstract: | |
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| Keywords: | Hepatitis B vaccine Perinatal transmission Rate of protection |
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