| HPLC法测定枸橼酸喷托维林片含量的测量不确定度评定 |
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| 引用本文： | 秦立,肖英,陈诗慧,范亚刚.HPLC法测定枸橼酸喷托维林片含量的测量不确定度评定[J].中国药师,2014(3):505-507. |
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| 作者姓名： | 秦立 肖英 陈诗慧 范亚刚 |
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| 作者单位： | 云南省食品药品检验所 昆明650011；;山东省食品药品检验所;云南中医学院;云南省食品药品检验所 昆明650011； |
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| 摘 要： | 目的：评定HPLC法测定枸橼酸喷托维林片含量的测量不确定度.方法：建立HPLC法测定含量的数学模型,分析测量不确定度的来源并对各分量进行量化分析和评估,合成标准测量不确定度,给出扩展测量不确定度报告.结果：HPLC法测定枸橼酸喷托维林片含量的扩展测量不确定度为2.4%,测量结果表示为（99.3±2.4）%,k=2.结论：分析产生不确定度的主要来源,为有效地控制该含量测定方法的准确性提供可靠的理论依据.
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| 关 键 词： | 测量不确定度 高效液相色谱法 枸橼酸喷托维林片 含量测定 |
| 收稿时间： | 2013/10/15 0:00:00 |
| 修稿时间： | 2013/12/10 0:00:00 |
Uncertainty Evaluation for Determination of Pentoxyverine Citrate Tablets by HPLC |
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| Qin Li,Xiao Ying,Chen Shihui and Fan Yagang.Uncertainty Evaluation for Determination of Pentoxyverine Citrate Tablets by HPLC[J].China Pharmacist,2014(3):505-507. |
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| Authors: | Qin Li Xiao Ying Chen Shihui and Fan Yagang |
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| Affiliation: | 1. Yunnan Institute for Food and Drug Control, Kunming 650011, China; 2. Shan- dong Institute for Food and Drug Control; 3. Yunnan University of Traditional Chinese Medicine) |
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| Abstract: | Objective： To evaluate the measurement uncertainty for the determination of pentoxyverine citrate tablets by HPLC. Methods： The mathematical model of content determination by HPLC was established. The uncertainty sources were analyzed. Each active component of uncertainty was calculated, and the extended uncertainty was obtained. Results： The extended uncertainty for the HPLC determination of pentoxyverine citrate was 2.4%, and the result of content determination was （ 99.3 ± 2.4 ） % （ k = 2 ）. Conclu- sion ： The main sources of uncertainty are analyzed, which provides the reliable theoretical basis for the effective control of the method. |
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| Keywords: | Measurement uncertainty HPLC Pentoxyverine citrate tablets Determination |
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