糖尿病合并脑梗死患者血清C反应蛋白水平的改变及与颈动脉斑块形成和高血压病的关系

目的探讨糖尿病合并脑梗死患者血清C反应蛋白(CRP)水平的改变及与颈动脉斑块形成和高血压病的关系。方法采用散射比色法检测103例糖尿病、240例急性脑梗死和130例糖尿病合并急性脑梗死患者的血清CRP水平;用彩色超声多普勒诊断仪检测颈动脉斑块;调查患者的高血压病史。结果糖尿病脑梗死组和急性脑梗死组的血清CRP水平、双侧颈动脉斑块形成和高血压病的比率及病程明显高于或长于糖尿病组(P<0.01～0.001);糖尿病脑梗死组高血压病程显著短于急性脑梗死组(P<0.05)。结论糖尿病合并急性脑梗死患者的血清CRP水平比糖尿病患者明显升高。双侧颈动脉斑块形成和高血压病(尤其病程长)是糖尿病并发ACI的主要因素。

Change of serum C-reactive protein level in patients with diabetes complicated cerebral infarction and relationship it and carotid plaque formation, hypertension

Objective To approach the change of serum C-reactive protein(CRP) level in patients with diabetes complicated acute cerebral infarction(DACI) and relationship between it and carotid plaque formation,hypertension.Methods The serum CRP level was detected by immune scattering chromatometry in 103 cases of diabetes,240 cases of acute cerebral infarction(ACI) and 130 cases of DACI.The carotid artery plaque was detected with color ultrasonic Doppler diagnostic apparatus.The hypertension history of all the patients was investigated.Results The serum CRP level,ratio of bilateral carotid plaque,hypertension and course of hypertension in the DACI group and ACI group were significantly higher or longer than those in the diabetic group(P<0.01-0.001).Thecourse of hypertension in DACI group was significantly shorter than ACI group(P<0.05).Conclusions The serum CRP level in patients with DACI is significantly higher than that in patients with diabetes.Bilateral carotid artery plaque formation and hypertension(especially long course) are main factors of DACI.