酒石酸长春瑞滨长循环热敏脂质体的荷瘤小鼠药效学研究

目的评价酒石酸长春瑞滨长循环热敏脂质体(V-LCTL)对荷瘤小鼠的药效和不良反应。方法建立荷Lewis肺癌小鼠皮下肿瘤模型,静脉注射药品,比较V-LCTL与酒石酸长春瑞滨注射液(V-I)、酒石酸长春瑞滨长循环脂质体(V-LCL)的抗肿瘤作用,包括肿瘤生长曲线,抑瘤率,考察给药频率及量效关系。结果各治疗组均有抑瘤作用。相同剂量下V-LCTL的抑瘤效果明显强于V-LCL和V-I。单次给药和多次给药对V-LCTL和V-I的抑瘤率无显著影响。单次给药时不良反应明显。V-LCTL的抑瘤效果呈剂量依赖性(低、中、高剂量组抑瘤率分别为54.6%,72.1%,81.5%)。结论 V-LCTL具有比V-I和V-LCL更好的抑瘤效果,多次给药不良反应小,且V-LCTL的抑瘤效果具有剂量依赖关系。

Pharmacodynamics of vinorelbine tartrate long-circulating thermosensitive liposomes in mice bearing Lewis lung carcinoma cells

Objective To investigate the tumor inhibition effect and toxicity of vinorelbine tartrate long-circulating thermosensitive liposome(V-LCTL) in mice bearing Lewis lung carcinoma cells.Methods A model of tumor-bearing mice was established by subcutaneous injection of Lewis lung cancer cells.The drug solution was intravenously administered to compare the anti-tumor effect of V-LCTL,vinorelbine tartrate long-circulating liposome(V-LCL) and vinorelbine tartrate injection(V-I).The tumor growth curve was obtained and the tumor inhibitory rate was calculated.The frequency of administration and dose-effect relationship of V-LCTL were systematically investigated.Results Each administered group showed inhibition effect on the growth of tumor.The inhibition effect of V-LCTL was better than that of V-LCL group and V-I group,respectively.Two methods of administration showed no significant difference in the inhibition rate of V-LCTL and V-I,but the toxicity and side effect of mice treated by single administration of 30 mg/kg were increased.There was a dose-effect relationship in the treatment of V-LCTL(54.6%,72.1%,and 81.5% in its low,medium and higher dose subgroups).Conclusion The inhibitory efficiency of V-LCTL is better than that of V-I and V-LCL.Three-time administration of V-LCTL decreases the toxicity and side effect.The tumor inhibitory effect of V-LCTL is positively correlated with the dose.