琥珀酸美托洛尔缓释片对冠心病无症状心肌缺血心率震荡和心率变异性的影响

目的 观察冠心病无症状心肌缺血心率震荡和心率变异性的改变及琥珀酸美托洛尔缓释片对心率震荡和心率变异性的影响.方法 对比观察美托洛尔治疗后的冠心病无症状心肌缺血患者心率震荡和心率变异性的改变,并与健康体检者对照.结果 治疗前,治疗组震荡斜率值、震荡初始值、SDNN、SDANN及SDNNindex明显低于对照组(P<0.05),rMSSD和PNN50与对照组比较差异无统计学意义(P>0.05);治疗后,震荡斜率值、震荡初始值、SDNN、SDANN及SDNNindex明显高于治疗前(P<0.05).结论 无症状心肌缺血患者存在心率震荡和心率变异性异常,美托洛尔可改善无症状心肌缺血患者心脏自主神经的调节功能.

Effects of Metoprolol Succinate Sustained-Release Tablets on Heart Rate Turbulence and Heart Rate Variability to Silent Ischemia with Coronary Heart Disease

Aim To investigate the effects of metoprolol succinate sustainedrelease tablets on heart rate turbulence (HRT) and heart rate variability (HRV) to silent ischemia with coronary heart disease.Methods The changes of heart rate turbulence and heart rate variability to silent ischemia with coronary heart disease in treatment with metoprolol were investigated.Results The TS and TO in treatment group were both lower than those of control group (P<0.05).The TS and TO after treatment were higher than those of before treatment.SDNN,SDANN and SDNNindex before treatment in treatment group except Rmssd and PNNS0 were lower than those of control group (P<0.05).SDNN,SDANN and SDNNindex after treatment in treatment group were increased significantly (P<0.05).Conclusion HRT and HRV in the patients of silent ischcmia with coronary heart disease is abnormal and metoprolol can improve the heart autonomic nerves function.