| 重离子治癌中剂量分布均匀度对肿瘤控制率的影响 |
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| 引用本文： | 温小琼,李强,周光明,李文建,卫增泉. 重离子治癌中剂量分布均匀度对肿瘤控制率的影响[J]. 辐射研究与辐射工艺学报, 2001, 19(3): 195-198 |
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| 作者姓名： | 温小琼 李强 周光明 李文建 卫增泉 |
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| 作者单位： | 中国科学院近代物理研究所 |
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| 基金项目： | 中国科学院留学经费择优支持基金 (HG0 0 0 6 0 2 )，教育部留学回国人员科研启动基金 |
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| 摘 要： | 为了把握重离子治癌中剂量分布的不均匀性对疗效的影响，我们研究了肿瘤控制率随剂量分布均匀度的变化。受不均匀重离子照射野照射时的细胞存活率理论与肿瘤控制率理论相结合，计算了一个假设肿瘤模型在不均匀剂量分布条件下的肿瘤控制率。结果表明：在相同的总剂量照射下，剂量分布均匀度越差肿瘤控制率越低。因此，在实际的治疗中，剂量分布均匀度应尽可能好于95％。
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| 关 键 词： | 重离子 剂量分布均匀度 肿瘤控制率 正常组织耐受性 肿瘤 放疗 |
| 修稿时间： | 2000-08-21 |
INFLUENCE OF DOSE DISTRIBUTION HOMOGENEITY ON THE TUMOR CONTROL PROBABILITY IN HEAVY-ION RADIOTHERAPY |
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| WEN Xiaoqiong LI Qiang ZHOU Guangming LI Wenjian WEI Zengquan. INFLUENCE OF DOSE DISTRIBUTION HOMOGENEITY ON THE TUMOR CONTROL PROBABILITY IN HEAVY-ION RADIOTHERAPY[J]. Journal of Radiation Research and Radiation Processing, 2001, 19(3): 195-198 |
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| Authors: | WEN Xiaoqiong LI Qiang ZHOU Guangming LI Wenjian WEI Zengquan |
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| Abstract: | In order to estimate the influence of the un-uniform dose distribution on the clinical treatment result,the Influence of dose distribution homogeneity on the tumor control probability was investigated. Basing on the formula deduced previously for survival fraction of cells irradiated by the un-uniform heavy-ion irradiation field and the theory of tumor control probability,the tumor control probability was calculated for a tumor mode exposed to different dose distribution homogeneity. The results show that the tumor control probability responding to the same total dose will decrease if the dose distribution homogeneity gets worse. In clinical treatment, the dose distribution homogeneity should be better than 95%. |
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| Keywords: | Heavy-ion Dose distribution homogeneity Tumor control probability Tolerance of normal tissues |
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