文拉法辛与米氮平治疗抑郁症的临床比较分析

目的 探测文拉法辛与米氮平各自的临床药理特征。方法 将68例文拉法辛与52例米氮平按不同的年龄分成三组,小于18岁共26例为A组即少年儿童组(其中文拉法辛16例,米氮平10例),18～60岁共70例为B组即成人组(其中文拉法辛40例,米氮平30例),大于60岁为C组即老年组共24例(共中文拉法辛组12例,米氮平组12例)。从药物的起效时间、症状改善时间,治疗后的HAMD总分及各因子分、TESS等方面进行对照结果:显示文拉法辛在少年儿童组起效最快,症状改善时间最短,成人组次之,老年组相对时间最长,但应引起临床注意的是转躁仅发生于服用文拉法辛少年儿童组且发生比例高,占41.67％,排尿困难多出现在成人及老年组,分别占2.5％及16.67％;而米氮平在老年患者中起效最快,症状改善时间最短,成年人次之,少年儿童改善时间相对最长,但需注意的是米氮平引起的低血压及癫痫失神发作仅出现在老年组,分别占8.33％及16.67％,治疗后的HAMD总分两组比较无显著差异,但米氮平在体重减轻、睡眠障碍两项因子分下降明显,而文拉法辛相对于迟缓、绝望感的因子分的下降更突出,焦虑/躯体化、认知障碍、日夜变化因子分的改善米氮平与文拉法辛显示了同样的疗效,TESS两组治疗后测定对照无显著差异。结论 两者均为一种起效快,副作用小的药物,各自的临床药理

Clinical comparative analysis of Venlafaxine versus Mirtazapine in the treatment of depression

Objective: To detect the clinical pharmacology characteristic of Venlafaxine and Mirtazap-ine. Methods: 68 Venlafaxine cases and Mirtazapine cases were divided into 3 agegroups: 26 cases aged below 18 referred to as 52 group A (16 childern group, cases of Venlafaxine and 10 cases of Mirtazapine) , 70 cases aged between 18 to 60 as grouup B (adults group, 40 cases of Venlafaxme and 30 cases of Mirtazapine) and 24 cases aged older 60 as group C ( aging grouup 12 cases of Venlafaxine and 12 cases of Mirtazapine). Following weasuces were componed between 2 groups: time of onset of respone, time symptom improveing, total score HAMD of and factor scores after treatment and TESS etc. Results: Venlafaxine shoued guicker quickly onset of response quickely became effective in childern group than in adults group and aging group. But is should be taken more clinical attention that, suritching into maniac occurred only in the children group taken Venalfaxine hydrochloride with ration of 41.67% ; dysuria occured in adults group and agine group, with frequeney of 2. 5% and 16.67% respectively. Mirtazapine shoued quicker enset of nespense became in old patients, then the time for in adults group and then in children group. It is necessary to pay more attention that, the low blood pressure and petit mal epilepsy occurred only in aging group, with occurred of 8.33% and 16.67% respecive-ly. HAMD total score of the two groups were not obviously different, after treatment but 2 factors score of the weight losing and the sleep disorder deereased mere eignificantry in Mirtazapine grouup clearly, he factors score of droehoride related to the retaidation and despair feeling decended outstandingly. Anxiety feeling/somatisa-tion, cognitive dysfumtion, and the Venlafaxine group transformation of day/night shown the same chamge in two groups. There was no difference in TESS scores hetmeen 2 group. Conclusion: Poth drugs hame quick respase and mild side effect. The respective clinical pharmacology characters shall contribute to select medicines under the clinical situation.