980例老年患者大肠埃希菌耐药性分析

目的了解老年患者感染大肠埃希菌的耐药性特征,为临床治疗及合理用药提供理论依据。方法收集我院2012年1月至2015年1月感染大肠埃希菌的老年患者病例980例,采用回顾性分析方法进行感染性状及耐药性分析,采用Kirby-Bauer纸片扩散法和CLSI 2013年版判断标准进行耐药性检测,并用SPSS 19.0统计软件进行数据分析。结果美罗培南耐药率最低,厄他培南其次,耐药率高于60%的抗菌药物分别为氨苄西林、哌拉西林、头孢唑林、头孢唑喃钠、头孢噻吩、氨苄西林/舒巴坦、环丙沙星、左氧氟沙星、左旋氧氟沙星、加替沙星、头孢呋辛、复方新诺明、头孢曲松、头孢噻肟。结论大肠埃希菌在老年患者中感染较为广泛,分离的大肠埃希菌的多重耐药率呈不断上升趋势,应根据药敏结果合理用药。

Drug resistance analysis of 980 elderly patients with Escherichia coli infection

Objective To investigate the resistance characteristics of elderly patients infected with Escherichia coli and provide a theoretical basis for clinical treatment and rational drug use. Methods 980 cases of elderly patients with Escherichia coli infection in our hospital from January 2012 to January 2015 were selected. Kirby-Bauer disc diffu-sion method and the judgment standard(CLSI edition,2013)were used to monitor the drug resistance,and SPSS 19. 0 statistical software was used for data analysis. Results The resistance rate of meropenem was the lowest,and ertapen-em followed. The antibiotics with esistance higher than 60% were ampicillin,piperacilli,cefazolin,cefuzonamsodium, cephalothin,ampicillin/sulbactam,ciprofloxacin,Levofloxacin,L-ofloxacin,gatifloxacin,cefuroxime,cotrimoxazole and ceftriaxone,cefotaxime. Conclusion Escherichia coli infections in elderly patients are popular,and separated multiple resistance of Escherichia coli has been rising,so rational drug use should be based on susceptibility results.