2, 3-二取代-5-乙烯基-4, 5-二氢呋喃的合成

为解决合成呋喃环需加入较多较昂贵的金属催化剂或者碱的问题,利用β-酮酯与对称的烯丙基二碳酸酯为原料,以烯丙基二碳酸酯的物质的量为用量标准,在以占标准用量2%的四(三苯基膦)钯与占标准用量2%的1,2-双-(二苯基膦)乙烷的作用下,合成了一系列的2,3-二取代-5-乙烯基-4,5-二氢呋喃衍生物。试验结果表明,取代基为吸电子基团时反应具有较高的产率,通过改变取代基,已得到了9个不同取代的2,3-二取代-5-乙烯基-4,5-二氢呋喃衍生物,所有产物结构均经1H及13C NMR确证。

The Synthesis of 2, 3-Bisubsituted-5-Vinyl-4, 5-Dihydrofuran

In order to solve the problems of adding expensive metal catalyst or alkali to synthesize furan ring, taking symmetrical allyl carbonate as the dosage standard, applies -ketoester and symmetrical allyl carbonate as raw materials to synthesize 2,3-bisubsituted-5-vinyl-4,5-dihydrofuran derivatives under the combined catalysis of the standard 2% tetrakis(triphenylphosphine)palladium catalyst and of the standard 2% 1,2-bis(diphenylphosphino)ethane. The experimental results show that the reaction has high yields with the electron withdrawing groups. By changing the substituents, obtains 9 different substituted 2,3-bisubsituted-5-vinyl-4,5-dihydrofuran derivatives. All products are confirmed by 1H and 13C NMR.